2013 Fiscal Year Final Research Report
Relation between epigenetic regulation by postprandial hyperglycemia and development of metabolic diseases
| Project/Area Number |
22680054
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Yamanashi (2011-2013)
University of Shizuoka (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | エピゲノム / 転写伸長 / Brd4 / 糖応答遺伝子 / 食習慣 / インスリン抵抗性 |
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| Research Abstract |
In this study, we found the Brd4 protein as a new epigenetic factor to enhance mRNA levels by leading histone modifications induced by carbohydrate intake. The Brd4 enhances transcription by recruiting positive elongation factor b (P-TEFb) on transcribed region of carbohydrate-responsive genes such as carbohydrate digestion and absorption-related genes in the small intestine and insulin sensitivity genes in adipocytes. In addition, we found that increased Brd4 expression induces obesity, insulin resistance in mice. Furthermore, we found Brd4 target proteins in blood such as ALBP, ALT are useful biomarkers for obesity and insulin resistance in human.
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[Journal Article] Induction of the BCMO1 gene during the suckling-weaning transition in rats is associated with histone H3 K4 methylation and subsequent coactivator binding and histone H3 acetylation to the gene2012
Author(s)
Mochizuki, H., Mochizuki K, , Suruga, K., Igarashi, M., Takase, S., Goda, T
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Journal Title
J Nutr Sci Vitaminol (Tokyo)
Volume: 58(5)
Pages: 319-26
Peer Reviewed
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