2012 Fiscal Year Final Research Report
Functional characterization of redox-sensitive ion channels usingchemical library
| Project/Area Number |
22681033
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | TRPチャネル / レドックス / カルシウムチャネル / ケミカルライブラリー |
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| Research Abstract |
In mammals, it is essential for our life to sense intracellular redox status. Recently, a class of TRP channels has been demonstrated to act as cell sensors for various environmental changes. In this research, we constructed chemical library having various redox properties to precisely characterize the redox sensitivity of TRP channels. Our characterization identified that TRPA1 is a highly sensitive channel for oxidation and reduction. Importantly, TRPA1 channel is activated by molecular oxygen, and critically contributes to oxygen-sensing mechanisms in mice.
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