2013 Fiscal Year Final Research Report
Development of material design for bio-absorbable composites toward tailor made medical treatments
| Project/Area Number |
22686014
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Materials/Mechanics of materials
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 生体吸収性プラスチック / ポリL乳酸 / 生体吸収性複合材料 / 高次構造 / 結晶化 / 配向 / マイクロメカニックス / 損傷力学 |
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| Research Abstract |
In order to realize a tailor-made medical treatment considering region and degree of disease, mechanical and hydrolysis properties for poly(L-lactic acid)/ tri-calcium phosphate composites were investigated experimentally and analytically as a function of the content of tri-calcium phosphate. Mechanical behavior was predicted based upon modified micromechanics. Molecular weight distributions, as hydrolysis behavior, were analytically predicted considering self-catalytic effect of carboxyl group. Since it is confirmed that variations in mechanical behavior associated with hydrolysis is caused by degradation around interphase between tri-calcium phosphate/ poly(L-lactic acid), mechanical behavior was predicted considering interfacial debonding with hydrolysis. In addition, mechanical properties of the composites were improved with an interfacial treatments.
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