2012 Fiscal Year Final Research Report
Impacts of nanoparticles on living bodies studied at the single-particle, single-cell level
| Project/Area Number |
22686072
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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| Research Institution | Kyoto University |
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Principal Investigator |
SHINTO Hiroyuki 京都大学, 大学院・工学研究科, 講師 (80324656)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ナノ粒子 / 表面官能基 / 接着性動物細胞 / 浮遊性動物細胞 / 赤血球 / 膜損傷 / 付着 / 飲食作用 |
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| Research Abstract |
We have investigated the impacts of nanoparticles on the different types of mammalian cells. It was found that the influential factors include not only the particle concentration and the incubation time, but the physicochemical properties of the particles, the incubation temperature, and the serum concentration in culture media, and that a balance among these factors determines the cellular responses. Especially, we have revealed the general mechanism how the size and surface properties of the particles affect the cell adhesion, cellular uptake, and cytotoxicity.
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