2012 Fiscal Year Final Research Report
Analysis of DNA repair pathway by the combination of proteomics andgenetic approach
| Project/Area Number |
22687001
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Genetics/Genome dynamics
|
|---|
| Research Institution | Tokyo Metropolitan University (2012)
Kyoto University (2010-2011) |
|---|
Principal Investigator |
HIROTA Kouji 首都大学東京, 大学院・理工学研究科, 教授 (00342840)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | DNA修復 / DNA損傷応答 / クロマチン / ユビキチン |
|---|
| Research Abstract |
In this study, we analyzed ubiquitylation signal pathway in DNA repair using the combination of proteomics and genetic approach. Our data figure out novel ubiquitin signal pathway, which is useful seeds targets for cancer chemotherapy.
|
Research Products
(22 results)
-
-
[Journal Article] Structure-specific endonucleases Xpf and Mus81 play overlapping but essential roles in DNA repair by homologous recombination2013
Author(s)
Kikuchi, K, Narita, T., Van, P.T., Iijima, J., Hirota, K., Keka, I.S.,Mohiuddin, Okawa, K., Hori, T., Fukagawa, T., Essers, J., Kanaar, R.,Whitby, M.C., Sugasawa, K., Taniguchi, Y., Kitagawa, K., and Takeda, S
-
Journal Title
-
-
-
-
-
-
-
-
[Journal Article] Simultaneous disruption of two DNA polymerases, Poleta and Polzeta, in Avian DT40 cells unmasks the role of Poleta in cellular response to various DNA lesions2010
Author(s)
K. Hirota, E. Sonoda, T. Kawamoto, A. Motegi, C. Masutani, F. Hanaoka, D. Szuts, S. Iwai, J. E. Sale, A.Lehmann and S. Takeda
-
Journal Title
-
-
-
-
[Journal Article] GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination2010
Author(s)
Y. Takizawa, Y. Qing, M. Takaku, T. Ishida, Y. Morozumi, T. Tsujita, T. Kogame, K. Hirota, M. Takahashi, T. Shibata, H. Kurumizaka and S. Takeda
-
Journal Title
-
-
-
-
-
-
-
-
