2013 Fiscal Year Final Research Report
Study on physiological function of a novel food intake-regulatory hypothalamic gene and its transcript
| Project/Area Number |
22687004
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphology/Structure
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 神経ペプチド / 視床下部 / 摂食調節 |
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| Research Abstract |
Recently, we have identified a novel hypothalamic gene which encodes a neuropeptide in the avian and mammalian brains. As the mRNA expression was changed during different energy states such as fasting and obesity, we predict that this novel gene may be involved in the energy homeostasis, especially food intake. In this study, we investigated the following analyses, identification of mature endogenous peptide, effect on food intake, histological relationships with known substances, regulatory mechanisms by peripheral substances, and phylogenetic analysis.
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Research Products
(28 results)
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[Journal Article] Identification of a cDNA encoding a novel small secretory protein, neurosecretory protein GL, in the chicken hypothalamic infundibulum2014
Author(s)
Ukena K, Iwakoshi-Ukena E, Taniuchi S, Bessho Y, Maejima S, Masuda K, Shikano K, Kondo K, Furumitsu M, Tachibana T.
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 446
Pages: 298-303
Peer Reviewed
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[Journal Article] Identification, localization and function of a novel neuropeptide, 26RFa, and its cognate receptor, GPR103, in the avian hypothalamus2013
Author(s)
Ukena K, Tachibana T, Tobari Y, Leprince J, Vaudry H, Tsutsui K
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Journal Title
Gen. Comp. Endocrinol
Volume: 190
Pages: 42-46
Peer Reviewed
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[Journal Article] Identification, localisation and functional implication of 26RFa orthologue peptide in the brain of zebra finch (Taeniopygia guttata)2011
Author(s)
Tobari Y, Iijima N, Tsunekawa K, Osugi T, Haraguchi S, Ubuka T, Ukena K, Okanoya K, Tsutsui K, Ozawa H
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Journal Title
J. Neuroendocrinol
Volume: 23
Pages: 791-803
Peer Reviewed
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[Journal Article] Identification, localization, and function of a novel avian hypothalamic neuropeptide, 26RFa, and its cognate receptor, G protein-coupled receptor-1032010
Author(s)
Ukena K, Tachibana T, Iwakoshi-Ukena E, Saito Y, Minakata H, Kawaguchi R, Osugi T, Tobari Y, Leprince J, Vaudry H, Tsutsui K
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Journal Title
Endocrinology
Volume: 151
Pages: 2255-2264
Peer Reviewed
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