2012 Fiscal Year Final Research Report
Structural Studies on Auto-regulatory Mechanism of Cyanobacterial Clock Proteins
| Project/Area Number |
22687010
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | Institute for Molecular Science (2012)
Nagoya University (2010-2011) |
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Principal Investigator |
AKIYAMA Shuji 分子科学研究所, 生命・錯体分子科学研究領域, 教授 (50391842)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 生物物理 / 生物時計 / 分光学 / 小角散乱 |
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| Research Abstract |
Dynamic structural change of the KaiC hexamer revealed in this study provides notable insights into the cyanobacterial circadian clock. Our model implies that KaiC ticks through expanding and contracting motions of the C2 ring. The timing of the accumulation of KaiC carrying the expanded C2 ring is coincident with that of accumulation of KaiC associated both with KaiA and KaiB. The conformational ticking of KaiC is likely to serve as a timing cue for assembly/disassembly of KaiA and KaiB.
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[Remarks] (1)秋山 修志, "生物の不思議 ～ 体内時計 ～", サイエンスキャンプ, 2010年8月, SPring-8(普及棟) アウトリーチ活動
