2012 Fiscal Year Final Research Report
Analysis of the roles of intracellular ATP during apoptosis by using the ATP imaging technique.
| Project/Area Number |
22687011
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | Kyoto University |
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Principal Investigator |
IMAMURA Hiromi 京都大学, 白眉センター, 准教授 (20422545)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞生物学 / 細胞死 / FRET |
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| Research Abstract |
In this study, we monitored intracellular ATP dynamics during apoptosis by using a newly developed caspase-resistant fluorescent ATP biosensor. We found that intracellular ATP level starts to decrease after the activation of caspase 3, and identified a molecule that is involved in declination of ATP. Moreover, we elucidated that intracellular ATP level regulates plasma membrane blebbing of apoptotic cells.
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