2013 Fiscal Year Final Research Report
Development of novel prognostic evaluation and therapy of hematological neoplasms in dogs and cats
| Project/Area Number |
22688026
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
FUJINO Yasuhito 東京大学, 農学生命科学研究科, 助教 (70401180)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | リンパ系腫瘍 / 肥満細胞腫 / 微小残存病変 / 分子標的療法 / 予後解析 |
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| Research Abstract |
The minimal residual disease assay by the gene analysis in canine lymphoid neoplasms was established and showed extremely useful for curative effect and a prognostic evaluation. In addition, plural tumor-related factors abnormality was clarified, and a part participated in the outcome and indicated to be with candidate novel treatment target molecules. Furthermore, the cytomorphological classification in feline lymphomas was established and it was clarified that the malignancy according to the classification was significantly associated with the outcome. On the other hand, antitumor effects of molecular target agents were analyzed in canine mastocytoma and the results showed potentials of novel treatment strategy. Furthermore, genetic mutations and the malignancy classification of canine mastocytoma participated in treatment efficacy and the outcome. The results are extremely useful for treatment guidelines and the prognostic evaluation in hematological neoplasms of animals.
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Research Products
(43 results)
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[Journal Article] Clinical characteristics and prognostic factors in dogs with histiocytic sarcomas in Japan2014
Author(s)
Takahashi M, Tomiyasu H, Hotta E, Asada H, Fukushima K, Kanemoto H, Fujino Y, Ohno K, Uchida K, Nakayama H, Tsujimoto H
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Journal Title
J Vet Med Sci
Volume: 76(5)
Pages: 661-6
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[Journal Article] Prognostic significance of the expression levels of the p16, p15, and p14 genes in dogs with high-grade lymphoma2014
Author(s)
Fujiwara-Igarashi A, Goto-Koshino Y, Sato M, Maeda S, Igarashi H, Takahashi M, Fujino Y, Ohno K, Tsujimoto H
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Journal Title
Vet J
Volume: 199(2)
Pages: 236-44
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[Journal Article] Development and evaluation of a novel in-clinic automated hematology analyzer, ProCyte Dx, for canine erythrocyte indices, leukogram, platelet counts and reticulocyte counts2013
Author(s)
Fujino Y, Nakamura Y, Matsumoto H, Fukushima K, Takahashi M, Ohno K, Tsujimoto H
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Journal Title
J Vet Med Sci
Volume: 75(11)
Pages: 1519-24
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[Journal Article] Validation of the prognostic value of histopathological grading or c-kit mutation in canine cutaneous mast cell tumours : a retrospective cohort study2013
Author(s)
Takeuchi Y, Fujino Y, Watanabe M, Takahashi M, Nakagawa T, Takeuchi A, Bonkobara M, Kobayashi T, Ohno K, Uchida K, Asano K, Nishimura R, Nakayama H, Sugano S, Ohashi Y, Tsujimoto H
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Journal Title
Vet J
Volume: 196(3)
Pages: 492-8
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[Journal Article] GeneScan analysis to detect clonality of T-cell receptor γ gene rearrangement in feline lymphoid neoplasms2012
Author(s)
Mochizuki H, Nakamura K, Sato H, Goto-Koshino Y, Sato M, Takahashi M, Fukushima K, Nakashima K, Fujino Y, Ohno K, Uchida K, Nakayama H, Tsujimoto H
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Journal Title
Vet Immunol Immunopathol
Volume: 145(1-2)
Pages: 402-9
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[Journal Article] Multiplex PCR and Genescan analysis to detect immunoglobulin heavy chain gene rearrangement in feline B-cell neoplasms2011
Author(s)
Mochizuki H, Nakamura K, Sato H, Goto-Koshino Y, Sato M, Takahashi M, Fujino Y, Ohno K, Uchida K, Nakayama H, Tsujimoto H
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Journal Title
Vet Immunol Immunopathol
Volume: 143(1-2)
Pages: 38-45
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[Journal Article] Establishment of a novel feline leukemia virus (FeLV)-negative B-cell cell line from a cat with B-cell lymphoma2011
Author(s)
Mochizuki H, Takahashi M, Nishigaki K, Ide T, Goto-Koshino Y, Watanabe S, Sato H, Sato M, Kotera Y, Fujino Y, Ohno K, Uchida K, Tsujimoto H
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Journal Title
Vet Immunol Immunopathol
Volume: 140(3-4)
Pages: 307-11
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