2013 Fiscal Year Final Research Report
Novel equilibrium control under transition-metal catalysis
| Project/Area Number |
22689001
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
ARISAWA MIEKO 東北大学, 薬学研究科(研究院), 准教授 (50302162)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 平衡制御 / 触媒反応 / 有機イオウ化合物 / 切断再配列 / へテロ元素捕捉剤 / 平衡相関 |
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| Research Abstract |
I found that transition-metal complexes could be used as catalyst for the synthesis and transformation of organosulfur compounds, and that a variety of reactions involving cleavage of heteroatom bonds such as C-S, C-F, C-C, C-O, S-S, P-P bonds were developed. The development of efficient catalysts, which decreases the activation energy of the reaction, provides equilibrium reactions, when the relative thermodynamic stabilities of the substrates and products are close. Then, equilibrium control methods using co-substrates and thermodynamically intermediate substrates were developed. Method employing the combination of transition-metal catalysis and equilibrium control can be generally used for the synthesis of organosulfur compounds.
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