2011 Fiscal Year Final Research Report
Molecular basis of Src-induced tumorigenesis
| Project/Area Number |
22689009
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 分子腫瘍学 / Src / ラフト / マイクロRNA |
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| Research Abstract |
In c-Src-induced transformation, we found that the lipid composition of rafts and the expression of lipid metabolism genes are changed. The addition of cholesterol to rafts efficiently suppressed c-Src-induced cell transformation. We also found that the miR-99a-mTOR/ FGFR3 pathway is crucial for controlling tumor growth and that c-Src. miR-542-3p. ILK. FAK circuit plays a pivotal role in controlling tumor progression. Our study provides insights into these novel signaling axes in the Src-related oncogenic pathway.
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[Journal Article] MicroRNA-mediated upregulation of integrin-linked kinase is crucial for Src-induced tumor progression2012
Author(s)
Oneyama C, Morii E, Okuzaki D, Takahashi Y, Ikeda J, Wakabayashi N, Akamatsu H, Tsujimoto M, Nishida T, Aozasa K, Okada M
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Journal Title
Oncogene
Volume: 31(13)
Pages: 1623-1635
DOI
Peer Reviewed
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