2013 Fiscal Year Final Research Report
Analysis of age-related diseases with oxidative stress in mitochondrial ROS-inducible model mice
| Project/Area Number |
22689012
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 酸化ストレス / ミトコンドリア / 習慣流産 / 不妊 / 神経変性疾患 / 学習記憶 / レドックスシグナル / マウス |
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| Research Abstract |
In this study, we focused on age-related diseases with oxidative stress. The age-dependent alterations of tissue functions caused by oxidative stress were analyzed in mitochondrial reactive oxygen species (ROS)-inducible model Tet-mev-1 mice. In the results, 1) low-birth-weight infants, 2) accelerated age-related corneal dysfunctions with dry eyes by lacrimal gland inflammations, 3) glial environmental defects in hippocampal regions with age, 4) recurrent abortions and maternal death, and 5) chronic hyperglycemia were confirmed as aging phenomena caused by mitochondrial oxidative stress. It was expecting that a means would be demonstrated to suppress the age-dependent homeostatic unbalanced alterations in individuals, when these molecular mechanisms would be clarified in this mouse model.
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