2012 Fiscal Year Final Research Report
Genome tailor-made evaluation of gout risk by molecular epidemiologic analysis toward early prevention of gout
| Project/Area Number |
22689021
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | National Defense Medical College |
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Principal Investigator |
MATSUO Hirotaka 防衛医科大学校, 医学教育部医学科専門課程, 講師 (00528292)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 分子遺伝疫学 / 予防医学 / 個人差医療 / 尿酸 / 遺伝統計学 / 個人差医療に基づく予防医学 |
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| Research Abstract |
In this study, we collected genome samples and clinical information from gout/hyperuricemia cases and controls. As a case only study, we genotyped 644 hyperuricemia patients for ABCG2 dysfunctional variants, which revealed that “decrease of extra-renal urate excretion is a common cause of hyperuricemia”（Nature Communications, 2012）. In addition, a genome wide association study of gout is also ongoing with the support of the Grant-in-Aid for Scientific Research on Innovative Areas ”Genome Sciences”. So far, we obtained several positive data by preliminary analysis, and we convince ourselves that we will report on the important gout susceptible genes soon.
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