2012 Fiscal Year Final Research Report
Systematic analyses of modes of migration, differentiation andfunction of bone-resorbing osteoclasts visualized by intravitalimaging
| Project/Area Number |
22689030
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Osaka University |
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Principal Investigator |
ISHII Masaru 大阪大学, 免疫学フロンティア研究センター, 特任教授 (10324758)
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| Project Period (FY) |
2010 – 2012
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| Keywords | リウマチ学 / 骨代謝 / 破骨細胞 / イメージング |
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| Research Abstract |
The main subject of this study is to reveal the cellular dynamics in various kinds of tissues and organs in vivo, by using advanced imaging techniques, especially focusing on the dynamic phenomenon within bone marrow cavity. By improving the optical technology, we developed an intravital bone imaging system that enabled elucidation of control mechanisms for dynamic behaviors of bone-resorbing osteoclasts in vivo. We also developed novel anti-bone resorptive treatments based on our findings.
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[Journal Article] Depletion of Jarid1b induces cellular senescence in human colorectal cancer2013
Author(s)
Ohta K, Haraguchi N, Kano Y, Kagawa Y, Konno M, Nishikawa S, Hamabe A, Hasegawa S, Ogawa H, Fukusumi T, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Noguchi Y, Ozaki M, Kudo T, Sakai D, Satoh T, Fukami M, Ishii M, Yamamoto H, Doki Y, Mori M, Is
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Journal Title
Int. J. Oncol
Volume: 42(4)
Pages: 1212-8
Peer Reviewed
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[Journal Article] Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques2013
Author(s)
Kotani M, Kikuta J, Klauschen F, Chino T, Kobayashi Y, Yasuda H, Tamai K, Miyawaki A, Kanagawa O, Tomura M, Ishii M
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Journal Title
J. Immunol
Volume: 190(2)
Pages: 605-12
Peer Reviewed
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[Journal Article] Dynamic visualization of RANKL and Th17-mediated osteoclast function2013
Author(s)
Kikuta J, Wada Y, Kowada T, Wang Z, Sun-Wada G-H, Nishiyama I, Mizukami S, Maiya N, Yasuda H, Kumanogoh A, Kikuchi K, Germain RN, Ishii M
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Journal Title
J. Clin. Invest
Volume: 123(2)
Pages: 866-873
Peer Reviewed
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[Journal Article] CognitionMaster: An Object-Based Image Analysis Framework2013
Author(s)
Wienert S, Heim D, Kotani M, Lindequist B, Stenzinger A, Ishii M, Hufnagl P, Beil M, Dietel M, Denkert C, Klauschen F
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Journal Title
Diagn. Pathol
Volume: 8
Pages: 34
Peer Reviewed
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[Journal Article] The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice2012
Author(s)
Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M*, Mochizuki N*
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Journal Title
J. Clin. Invest
Volume: 122(4)
Pages: 1416-1426
Peer Reviewed
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[Journal Article] Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis2012
Author(s)
Kayama H, Ueda Y, Sawa Y, Jeon SG, Ma JS, Okumura R, Kubo A, Ishii M, Okazaki T, Murakami M, Yamamoto M, Yagita H, Takeda K
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 109(13)
Pages: 5010-5015
Peer Reviewed
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[Journal Article] PDGFRα-positive cells in bone marrow are mobilized by HMGB1 to regenerate injured epithelia2011
Author(s)
Tamai K, Yamazaki T, Chino T, Ishii M, Otsuru S, Kikuchi Y, Iinuma S, Saga K, Nimura K, Shimbo T, Umegaki N, Katayama I, Miyazaki J, Takeda J, McGrath J, Uitto J, Kaneda Y.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 108(16)
Pages: 6609-6614
Peer Reviewed
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