Identifying genetic factors for deficits in interpersonal behaviors by utilizing multimodal Magnetic Resonance Imaging

2013 Fiscal Year Final Research Report

• Project/Area Number: 22689034
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: YAMASUE Hidenori 東京大学, 医学部附属病院, 准教授 (80436493)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Keywords: 社会性の障害 / 自閉症スペクトラム障害 / 統合失調症 / オキシトシン受容体遺伝子多型 / 内側前頭前野 / 島皮質

Research Abstract

This study project revealed associations between OXTR rs2254298a, a risk allele for autism spectrum disorders (ASD) in Asian populations, and regional gray matter volumes in limbic and paralimbic brain structures (Biol Psychiatry 2010a; 2011; SCAN 2013). Effects of exogenous oxytocin on phenotype/endophenotype of oxytocin related genetic factors were further tested by conducting a randomized controlled double-blind trial (J Neurosci 2012; JAMA psychiatry 2014). Furthermore, common and distinct contributions of medial prefrontal and inferior frontal cortices to the brain pathophysiology for schizophreina and ASD were revealed (e.g. Biol Psychiatry 2010b; Transl Psychiatry 2012; Schizophr Bull 2013).

Research Products

• [Journal Article] Two distinct neural mechanisms underlying indirect reciprocity (2014)
  • Author(s): Watanabe T, Takezawa M, Nakawake Y, Kunimatsu A, Yamasue H, Nakamura M, et al
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 111(11) Pages: 3990-3995
  • DOI: 10.1073/pnas.1318570111
• [Journal Article] A snapshot of plasma metabolites in first-episode schizophrenia : A capillary electrophoresis time-of-flight mass spectrometry study (131 characters) (2014)
  • Author(s): Koike S, Bundo M, Iwamoto K, Suga M, Kuwabara H, Ohashi Y, Shinoda K, Takano Y, Iwashiro N, Satomura Y, Nagai T, Natsubori T, Tada M, Yamasue H, and Kasai K
  • Journal Title: Translational Psychiatry Volume: 4 Pages: e379
  • DOI: 10.1038/tp.2014.19
• [Journal Article] Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals (2014)
  • Author(s): Nishimura Y, Takizawa R, Koike S, Kinoshita A, Satomura Y, Kawasaki S, Yamasue H, Tochigi M, Kakiuchi C, Sasaki T, Iwayama Y, Yamada K, Yoshikawa T, and Kasai K
  • Journal Title: NeuroImage Volume: 1 Pages: 527-34
  • DOI: 10.1016/j.neuroimage.2013.08.021
• [Journal Article] Aberrant interference of auditory negative words on attention in patients with schizophrenia (2013)
  • Author(s): Iwashiro N, Yahata N, Kawamuro Y, Kasai K, and Yamasue H
  • Journal Title: PLOS ONE Volume: 8 Pages: e83201
  • DOI: 10.1371/journal.pone.0083201
• [Journal Article] Prefrontal activation during inhibitory control measured by near-infrared spectroscopy for differentiating between autism spectrum disorders and attention deficit hyperactivity disorder in adults (2013)
  • Author(s): Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Kuwabara H, Matsubayashi J, Hamada K, Okuhata S, Yahata N, Igarashi T, Kawasaki S, Yamasue H, Kato N, Kasai K, and Kano Y
  • Journal Title: Neuroimage : Clinical Volume: 4 Pages: 53-63
  • DOI: 10.1016/j.nicl.2013.10.002
• [Journal Article] Neural correlate of autistic-like traits and a common allele in the oxytocin receptor gene (2013)
  • Author(s): Saito Y, Suga M, Tochigi M, Abe O, Yahata N, Kawakubo Y, Liu X, Kawamura Y, Sasaki T, Kasai K, and Yamasue H
  • Journal Title: Social Cognitive and Affective Neuroscience Volume: (published online)
  • DOI: 10.1093/scan/nst136
• [Journal Article] Reduced frontal Glutamate+Glutamine and N-acetylaspartate levels in patients with chronic schizophrenia but not in those at clinical-high risk for psychosis or with first-episode schizophrenia (2013)
  • Author(s): Natsubori T, Inoue H, Abe O, Takano Y, Iwashiro N, Aoki Y, Koike S, Yahata N, Katsura M, Gonoi W, Sasaki H, Takao H, Kasai K, and Yamasue H
  • Journal Title: Schizophrenia Bulletin Volume: (published online)
  • DOI: 10.1093/schbul/sbt124
• [Journal Article] Altered metabolites in the plasma of autism spectrum disorder : a capillary electrophoresis time-of-flight mass spectroscopy study (2013)
  • Author(s): Kuwabara H, Yamasue H, Koike S, Inoue H, Kawakubo Y, Kuroda M, Takano Y, Iwashiro N, Natsubori T, Aoki Y, Kano Y, and Kasai K
  • Journal Title: PLOS ONE Volume: 8 Pages: e73814
  • DOI: 10.1371/journal.pone.0073814
• [Journal Article] Neural bases of antisocia behavior : a voxel-based meta-analysis (2013)
  • Author(s): Aoki Y, Inokuchi R, Nakao T and Yamasue H
  • Journal Title: Social Cognitive and Affective Neuroscience Volume: (published online)
  • DOI: 10.1093/scan/nst104
• [Journal Article] Mitigation of Sociocommunicational Deficits of Autism Through Oxytocin-Induced Recovery of Medial Prefrontal Activity : A Randomized Trial (2013)
  • Author(s): Watanabe T, Abe O, Kuwabara H, Yahata N, Takano Y, Iwashiro N, Natsubori T, Aoki Y, Takao H, Kawakubo Y, Kamio Y, Kato N, Miyashita Y, Kasai K, and Yamasue H
  • Journal Title: JAMA psychiatry Volume: 71 Pages: 166-75
  • DOI: 10.1001/jamapsychiatry.2013.3181
• [Journal Article] Comparison of white matter integrity between autism spectrum disorder subjects and typically developing individuals. A meta-analysis of diffusion tensor imaging tractography studies (2013)
  • Author(s): Aoki Y, Abe O, Nippashi Y and Yamasue H
  • Journal Title: Molecular Autism Volume: 4(1) Pages: 25
  • DOI: 10.1186/2040-2392-4-25
• [Journal Article] Volume reductions in frontopolar and left perisylvian cortices in methamphetamine induced psychosis (2013)
  • Author(s): Aoki Y, Orikabe L, Takayanagi Y, Yahata N, Mozue Y, Sudo Y, Ishii T, Itokawa M, Suzuki M, Kurachi M, Okazaki Y, Kasai K, Yamasue H
  • Journal Title: Schizophrenia Research Volume: 147 Pages: 355-361
  • DOI: 10.1016/j.schres.2013.04.029
• [Journal Article] Network structure underlying resolution of conflicting nonverbal and verbal social information (2013)
  • Author(s): Watanabe T, Yahata N, Kawakubo Y, Inoue H, Takano Y, Iwashiro N, Natsubori T, Takao H, Sasaki H, Gonoi W, Murakami M, Katsura M, Kunimatsu A, Abe O, Kasai K, Yamasue H
  • Journal Title: Social Cognitive and Affective Neuroscience Volume: (published online)
  • DOI: 10.1093/scan/nst046
• [Journal Article] Absence of age-related prefrontal NAA change in adults with autism-spectrum disorders (2012)
  • Author(s): Aoki Y, Abe O, Yahata N, Kuwabara H, Natsubori T, Iwashiro N, Takano N, Inoue H, Kawakubo Y, Gonoi W, Sasaki H, Murakami M, Katsura M, Nippashi Y, Takao H, Kunimatsu A, Matsuzaki H, Tsuchiya KJ, Kato N, Kasai K, Yamasue H
  • Journal Title: Translational Psychiatry Volume: 2 Pages: e178
  • DOI: 10.1038/tp.2012.108
• [Journal Article] Clinical and psychosocial characteristics in adults with pervasive development disorders : A survey in Japan (2012)
  • Author(s): Yukawa Y, Ota H, Kanai C, Tani M, Yamada T, Hashimoto R, Yamasue H, Kato N, Iwanami A
  • Journal Title: International Journal on Disability and Human Development Volume: 12 Pages: 25-29
  • DOI: 10.1515/ijdhd-2012-0121
• [Journal Article] Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia (2012)
  • Author(s): Iwashiro N, Suga M, Takano Y, Inoue H, Natsubori T, Satomura Y, Koike S, Yahata N, Murakami M, Katsura M, Gonoi W, Sasaki H, Takao H, Abe O, Kasai K, Yamasue H
  • Journal Title: Schizophrenia Research Volume: 137 Pages: 124-31
  • DOI: 10.1016/j.schres.2012.02.024
• [Journal Article] Age-related change in brain metabolite abnormalities in autism : A meta-analysis of proton magnetic resonance spectroscopy studies (2012)
  • Author(s): Aoki Y, Kasai K, Yamasue H
  • Journal Title: Translational Psychiatry Volume: 2 Pages: e69
  • DOI: 10.1038/tp.2011.65
• [Journal Article] Diminished medial prefrontal activity behind autistic social judgments of incongruent information (2012)
  • Author(s): Watanabe T, Yahata N, Abe O, Kuwabara H, Inoue H, Takano Y, Iwashiro N, Natsubori T, Aoki Y, Takao H, Sasaki H, Gonoi W, Murakami M, Katsura M, Kunimatsu A, Kawakubo Y, Matsuzaki H, Tsuchiya KJ, Kato N, Kano Y, Miyashita Y, Kasai K, Yamasue H
  • Journal Title: PLoS One Volume: 7 Pages: e39561
  • DOI: 10.1371/journal.pone.0039561
• [Journal Article] Reply to "Neurogenetic effects of OXTR rs2254298 in the extended limbic system of healthy Caucasian adults" (2011)
  • Author(s): Yamasue H, Suga M, Yahata N, Inoue H, Tochigi M Abe O, Liu X, Kawamura Y, Rogers MA, Takei K, Yamada H, Aoki S, Sasaki T, Kasai K
  • Journal Title: Biological Psychiatry Volume: 70 Pages: 41-42
  • DOI: 10.1016/j.biopsych.2011.06.034
• [Journal Article] Reduced amygdala and hippocampal volumes in patients with methamphetamine psychosis (2011)
  • Author(s): Orikabe L, Yamasue H, Inoue H, T Yoichiro, Mozue Y, Sudo Y, Ishii T, Itokawa M, Suzuki M, Kurachi M, Okazaki Y, Kasai K
  • Journal Title: Schizophrenia Research Volume: 132 Pages: 183-189
  • DOI: 10.1016/j.schres.2011.07.006
• [Journal Article] Association between the oxytocin receptor gene (OXTR) and amygdalar volume in healthy adults (2010)
  • Author(s): Inoue H, Yamasue H, Tochigi M, Abe O, Liu X, Kawamura Y, Takei K, Suga M, Yamada H, Rogers MA, Aoki S, Sasaki T, Kasai K
  • Journal Title: Biological Psychiatry Volume: 68 Pages: 1066-1072
  • DOI: 10.1016/j.biopsych.2010.07.019
• [Journal Article] Reduced gray matter volume of Brodmann's Area 45 is associated with severe psychotic symptoms in patients with schizophrenia (2010)
  • Author(s): Suga M, Yamasue H, Abe O, Yamasaki S, Yamada H, Inoue H, Takei K, Aoki S, Kasai K
  • Journal Title: European Archives of Psychiatry and Clinical Neuroscience Volume: 260 Pages: 465-473
  • DOI: 10.1007/s00406-009-0094-1
• [Journal Article] Reduced gray matter volume of pars opercularis is associated with impaired social communication in high-functioning autism spectrum disorders (2010)
  • Author(s): Yamasaki S, Yamasue H, Abe O, Suga M, Yamada H, Inoue H, Kuwabara H, Kawakubo Y, Yahata N, Aoki S, Kano Y, Kato N, Kasai K
  • Journal Title: Biological Psychiatry Volume: 68 Pages: 1141-1147
  • DOI: 10.1016/j.biopsych.2010.07.012
• [Journal Article] Effect of tryptophan hydroxylase-2 gene variants on amygdalar and hippocampal volumes (2010)
  • Author(s): Inoue H, Yamasue H, Tochigi M, Takei K, Suga M, Abe O, Yamada H, Rogers MA, Aoki S, Sasaki T, Kasai K
  • Journal Title: Brain Research Volume: 1331 Pages: 51-57
  • DOI: 10.1016/j.brainres.2010.03.057
• [Journal Article] Functional (GT)n polymorphismsin promoter region of N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene affect hippocampal and amygdala volumes (2010)
  • Author(s): Inoue H, Yamasue H, Tochigi M, Suga M, Iwayama Y, Abe O, Yamada H, Rogers MA, Aoki S, Kato T, Sasaki T, Yoshikawa T, Kasai K
  • Journal Title: Genes, Brain and Behavior Volume: 9 Pages: 269-275
  • DOI: 10.1111/j.1601-183X.2009.00557.x
• [Presentation] Absence of age-related prefrontal NAA change in adults with autism-spectrum disorders (2012)
  • Author(s): Aoki Y, Abe O, Yahata N, Kuwabara H, Iwashiro N, Natsubori T, Takano Y, Inoue H, Kawakubo Y, Gonoi W, Sasaki H, Murakami M, Katsura M, Nippashi Y, Takao H, Kunimatsu A, Matsuzaki H, Tsuchiya KJ, Kato N, Kasai K, Yamasue H
  • Organizer: Neuroscience 2012, SfN's 42nd annual meeting
  • Place of Presentation: New Orleans
  • Year and Date: 2012-10-13
• [Presentation] Atypical age-related change ofmedial prefrontal N-acetylaspartate in adults with autismspectrum disorder : a protonmagnetic resonance (2012)
  • Author(s): Aoki Y, Abe O, Yahata N, Kuwabara H, Natsubori T, Iwashiro N, Takano Y, Takao H, Kato N, Yamasue H
  • Organizer: 20th WORLD CONGRESS PARIS IACAPAP 2012
  • Place of Presentation: Paris, France
  • Year and Date: 2012-07-24
• [Presentation] A Meta Analytic Approach of Proton Magnetic Resonance Spectroscopy Studies to Uncover the Background of Transient Overgrowth of Autistic Brain (2012)
  • Author(s): Aoki Y, Kasai K, Yamasue H
  • Organizer: 2012 SOBP 67th Annual Scientific Convention
  • Place of Presentation: Philadelphia
  • Year and Date: 2012-05-04
• [Presentation] Are Autistic Brain Structural Abnormalities Associated with Perinatal and Genetic Factors? (2012)
  • Author(s): Yamasue H, Kuwabara H, Aoki Y, Saito Y, Yahata N, Natsubori T, , Iwashiro N, Takano Y, Inoue H, Nippashi Y, Takao H, Abe O, Sasaki T, Kasai K
  • Organizer: 2012 SOBP 67th Annual Scientific Convention
  • Place of Presentation: Philadelphia
  • Year and Date: 2012-05-04
• [Presentation] 双生児研究法による近赤外線スペクトロスコピーの前頭側頭部血流変化における遺伝的要因の検討 (2012)
  • Author(s): 榊原英輔, 滝沢龍, 西村幸香, 木納賢, 丸茂浩平, 山崎修道, 江口聡, 武井邦夫, 井上秀之, 管心, 山末英典, 川久保友紀, 笠井清登
  • Organizer: 第7回統合失調症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-03-17
• [Presentation] 所初統合失調症群と精神病状態の高リスク群に共通して認められる下前頭回における三角部に局限した灰白質体積減少とその陽性症状発現との関連 (2012)
  • Author(s): 岩白訓周, 管心, 高野洋輔, 井上秀之, 夏堀龍暢, 里村嘉弘, 小池進介, 八幡憲明, 村上瑞穂, 五ノ井渉, 佐々木弘喜, 高尾英正, 阿部修, 笠井清登, 山末英典
  • Organizer: 第7回統合失調症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-03-16
• [Presentation] 双生児研究法による新版S タイ状態-特性不安検査と近赤外線スペクトロスコピーにおける遺伝的要因の検討 (2012)
  • Author(s): 榊原英輔, 滝沢龍, 西村幸香, 木納賢, 丸茂浩平, 山崎修道, 江口聡, 武井邦夫, 井上秀之, 管心, 山末英典, 川久保友紀, 笠井清登
  • Organizer: 第4回日本不安障害学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-02-04
• [Presentation] Investigating neural mechanisms that interface between self and others : An fMRI study on the theory of mind and empathy (2011)
  • Author(s): Yahata N, Yamasue H, Takano Y, Kawakubo Y, Inoue H, Iwashiro N, Natsubori T, Aoki Y, Takao H, Sasaki H, Gonoi W, Katsura M, Murakami M, Kunimatsu A, Abe O, Kasai K
  • Organizer: Neuroscience 2011, SfN's 41th annual meeting
  • Place of Presentation: Washington, DC
  • Year and Date: 2011-11-16
• [Presentation] Intranasal administration of oxytocin recovers deficits in social interaction with increase of originally decreased medial prefrontal activity in autism spectrum disorder (2011)
  • Author(s): Yamasue H, Wtanabe T, Abe O. Yahata N, Kuwabara H, Inoue H, Takanano Y, Iwashiro N, Natsubori T, Aoki Y, Takao H, Sasaki H, Gonoi W, Murakami M, Katsura M, Kunimatsu A, Kawakubo Y, Ando T, Suga M, Matsuzaki H, Tsuchiya K, Kamio Y, Kato N, Kano Y, Miyashita Y, Kasai K
  • Organizer: Neuroscience 2011, SfN's 41th annual meeting
  • Place of Presentation: Washington, DC
  • Year and Date: 2011-11-15
• [Presentation] 自閉症当事者の内側前頭前野における神経科学的変化 (2011)
  • Author(s): 青木悠太, 山末英典, 阿部修, 八幡憲明, 夏堀龍暢, 岩白訓周, 高野洋輔, 井上秀之, 桑原斉, 川久保友紀, 五ノ井渉, 佐々木弘喜, 村上瑞穂, 桂正樹, 新橋靖真, 高尾英正, 国松聡, 松崎秀夫, 土屋賢治, 笠井清登
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] 自閉症の脳形態特徴 : VBM 研究 (2011)
  • Author(s): 齋藤有希, 山末英典, 八幡憲明, 夏堀龍暢, 青木悠太, 岩白訓周, 高野洋輔, 桑原斉, 川久保友紀, 五ノ井渉, 佐々木弘喜, 村上瑞穂, 桂正樹, 新橋靖真, 高尾英正, 国松聡, 阿部修, 松崎秀夫, 土屋賢治, 笠井清登
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] 統合失調症患者における作動記憶の下位項目の障害の神経関連 : fMRI 研究 (2011)
  • Author(s): 夏堀龍暢, 山末英典, 八幡憲明, 岩白訓周, 高野洋輔, 井上秀之, 五ノ井渉, 村上瑞穂, 桂正樹, 佐々木弘喜, 高尾英正, 国松聡, 阿部修, 笠井清登
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] 統合失調症発症前後における下前頭回の灰白質体積の変化 (2011)
  • Author(s): 岩白訓周, 山末英典, 管心, 夏堀龍暢, 高野洋輔, 井上秀之, 里村嘉弘, 小池進介, 八幡憲明, 村上瑞穂, 桂正樹, 五ノ井渉, 佐々木弘喜, 高尾英正, 阿部修, 笠井清登
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] Neuroanatomical basis of subclinical autistic trait (2011)
  • Author(s): Saito H, Yamasue H, Abe O, Suga M, Yahata N, Kawakubo Y, Kasai K, Yamada H, Aoki S
  • Organizer: 10th WFSBP Congres
  • Place of Presentation: Prague, Czeck Republic
  • Year and Date: 2011-06-01
• [Presentation] Gray matter volume changes of subregions in inferior frontal gyrus around the onset of psychosis (2011)
  • Author(s): Iwashiro N, Yamasue H, Suga M, Takano Y, Inoue H, Yahata N, Sasaki H, Takao H, Abe O, Kasai K
  • Organizer: 10th WFSBP Congres
  • Place of Presentation: Prague, Czeck Republic
  • Year and Date: 2011-05-30
• [Presentation] アスペルガー障害のNIRS 所見 : 言語流暢性課題を用いて (2011)
  • Author(s): 岩波明, 岡島由佳, 太田晴久, 山田貴志, 谷将之, 橋本龍一郎, 金井智恵子, 渡部洋実, 川久保友紀, 山末英典, 加藤進昌
  • Organizer: 第33回生物学的精神医学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-22
• [Presentation] Blonanserin内服中に高度徐脈を呈した統合失調症の一例 (2010)
  • Author(s): 杉下和行, 音羽健司, 蒲谷洋平, 荒木剛, 山末英典, 笠井清登
  • Organizer: 第106回日本精神神経学会学術総会
  • Place of Presentation: 広島
  • Year and Date: 20100500
• [Presentation] Association between the oxytocin receptor gene (OXTR) and amygdalar volume in healthy adults (2010)
  • Author(s): Inoue H, Yamasue H, Tochigi M , Abe O, Takei K, Suga M, Yamada H, Rogers MA, Aoki S, Liu X, Kawamura Y, Sasaki T, Kasai K
  • Organizer: Neuroscience 2010, SfN's 40th annual meeting
  • Place of Presentation: San Diego
  • Year and Date: 2010-11-16
• [Presentation] Reduced gray matter volumeof pars opercularis is associated with impaired social communication in high-functioning autism spectrum disorders (2010)
  • Author(s): Yamasue H, Yamasaki S, Abe O, Suga M, Yamada H, Inoue H, Kuwabara H, Kawakubo Y, Aoki S, Kano Y, Kato N, Kasai K
  • Organizer: Neuroscience 2010, SfN's 40th annual meeting
  • Place of Presentation: San Diego
  • Year and Date: 2010-11-14
• [Presentation] 自閉症傾向の脳形態基盤 (2010)
  • Author(s): 齋藤有希, 山末英典, 阿部修, 管心, 八幡憲明, 川久保友紀, 山田晴耕, 青木茂樹, 笠井清登
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 北九州
  • Year and Date: 2010-10-09
• [Presentation] ARMS(at risk mental state)群と初発統合失調症群における下前頭回の灰白質体積減少 (2010)
  • Author(s): 岩白訓周, 山末英典, 管心, 夏堀龍暢, 高野洋輔, 井上秀之, 里村嘉弘, 小池進介, 八幡憲明, 村上瑞穂, 桂正樹, 五ノ井渉, 佐々木弘喜, 高尾英正, 阿部修, 笠井清登
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 北九州
  • Year and Date: 2010-10-09
• [Presentation] 統合失調症における単語の意味および語彙判断のプログラミング効果のfMRI 研究 (2010)
  • Author(s): 夏堀龍暢, 山末英典, 八幡憲明, 橋本龍一郎, 井上秀之, 高野洋輔, 岩白訓周, 武井邦夫, 五ノ井渉, 佐々木弘喜, 高尾英正, 阿部修, 笠井清登
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 北九州
  • Year and Date: 2010-10-09
• [Presentation] 統合失調症における臨床病期の進行に伴うグルタミン酸神経系の異常 : 3 テスラMRS を用いた検討 (2010)
  • Author(s): 井上秀之, 山末英典, 阿部修, 八幡憲明, 高野洋輔, 岩白訓周, 夏堀龍暢, 武井邦夫, 小池進介, 村上瑞穂, 桂正樹, 五ノ井渉, 佐々木弘喜, 高尾英正, 笠井清登
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 北九州
  • Year and Date: 2010-10-08
• [Presentation] 共感の神経基盤における男女差の検討 : fMRI 研究 (2010)
  • Author(s): 高野洋輔, 山末英典, 八幡憲明, 橋本龍一郎, 五ノ井渉, 佐々木弘喜, 高尾英正, 夏堀龍暢, 岩白訓周, 井上秀之武井邦夫, 阿部修, 笠井清登
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] オキシトシン受容体多型(OXTR)が扁桃体体積に与える影響 (2010)
  • Author(s): 井上秀之, 山末英典, 栃木衛, 阿部修, 武井邦夫, 管心, 山田晴耕, Rogers MA, 青木茂樹, 劉暁渓, 河村代志也, 佐々木司, 笠井清登
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Book] ブレインサイエンスレビュー2012, 多面的脳MRI による対人行動の障害の研究 (2012)
  • Author(s): 山末英典
  • Total Pages: 185-204
  • Publisher: クバプロ
• [Book] アスペハート, 特集 自閉症はどこまでわかってきたのか-生物学的精神医学研究と支援をつなげる, 脳の機能・形態の問題として明らかになったこと-MRI 研究が明らかにしたこと (2011)
  • Author(s): 山末英典
  • Total Pages: 40-44
  • Publisher: アスペ・ベルデの会
• [Book] 精神医学キーワード事典, 12章脳画像, 脳生理学, 208「自閉症スペクトラム障害の脳画像研究」 (2011)
  • Author(s): 山末英典
  • Total Pages: 573-575
  • Publisher: 中山書店
• [Book] 精神医学キーワード事典, 12章脳画像, 脳生理学, 206「初期統合失調症の脳画像」 (2011)
  • Author(s): 山末英典
  • Total Pages: 567-569
  • Publisher: 中山書店
• [Book] 『精神科 研修ノート』 第2章 精神科研修でマスターすべきこと, B 脳科学からのアプローチ, 2.脳と精神障害の関連 (2011)
  • Author(s): 山末英典
  • Total Pages: 104-106
  • Publisher: 診断と治療社
• [Book] 『専門医のための精神科臨床リュミエール』21巻 前頭葉でわかる精神疾患の臨床, III. 精神疾患における前頭葉の構造と機能 4. PTSD (2010)
  • Author(s): 山末英典
  • Total Pages: 12-129
  • Publisher: 中山書店
• [Book] 『専門医のための精神科臨床リュミエール』19巻 広汎性発達障害-自閉症へのアプローチ, II. 理論編 5. 広汎性発達障害の画像研究 (2010)
  • Author(s): 山末英典
  • Total Pages: 40-46
  • Publisher: 中山書店
• [Book] 『専門医のための精神科臨床リュミエール』16巻 脳科学エッセンシャル-精神疾患の生物学的理解のために, III. 中枢神経の構造と機能 I.辺縁系と視床下部, 2.帯状皮質と情動 (2010)
  • Author(s): 山末英典
  • Total Pages: 105-106
  • Publisher: 中山書店