2012 Fiscal Year Final Research Report
Retinal Vascular Regeneration by Rectifying Angiogenic Directions
| Project/Area Number |
22689046
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kobe University |
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Principal Investigator |
UEMURA Akiyoshi 神戸大学, 大学院・医学研究科, 特命助教 (30373278)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUSHIMA Yoko 神戸大学, 大学院・医学研究科, 研究員 (70647031)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 血管新生 / 内皮細胞 / 糸状仮足 / Sema3E / PlexinD1 / RhoJ / Arhgef15 / VEGF |
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| Research Abstract |
We attempted to develop a modality by which angiogenic directions are rectified in ischemic retinopathy. During development, binding of neuron-derived Sema3E to endothelial PlexinD1 activated RhoJ, thereby retracting disoriented angiogenesis. In a mouse model of ischemic retinopathy, intravitreal injections of Sema3E protein selectively prevented disoriented angiogenesis without affecting retinal vascular regeneration. Theses results present a new paradigm of vascular regeneration therapy that guides new blood vessels toward the ischemic retinas.
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Research Products
(25 results)
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[Journal Article] Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells2012
Author(s)
Kusuhara S, Fukushima Y, Fukuhara A, Jakt LM, Okada M, Shimizu Y, Hata M, Nishida K, Negi A, Hirashima M, Mochizuki N, Nishikawa S, Uemura A
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Journal Title
PLoS ONE
Volume: 7
Pages: e45858
DOI
Peer Reviewed
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[Journal Article] Angiopoietin-2 differentially regulates angiogenesis through Tie2 and integrin signaling2012
Author(s)
Felcht M, Luck R, Schering A, Seidel P, Srivastava K, Hu J, Bartol A, Kienast Y, Vettel C, Loos EK, Kutschera S, Bartels S, Appak S, Besemfelder E, Terhardt D, Chavakis E, Wieland T, Klein C, Thomas M, Uemura A, Goerdt S, Augustin HG
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Journal Title
J Clin Invest
Volume: 122
Pages: 1991-2005
Peer Reviewed
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[Journal Article] The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice2012
Author(s)
Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M, Mochizuki N
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Journal Title
J Clin Invest
Volume: 122
Pages: 1416-1426
Peer Reviewed
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[Journal Article] Inhibition of semaphorin as a novel strategy for therapeutic angiogenesis2010
Author(s)
Moriya J, Minamino T, Tateno K, Okada S, Uemura A, Shimizu I, Yokoyama M, Nojima A, Okada M, Koga H, Komuro I
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Journal Title
Circ Res
Volume: 106
Pages: 391-398
Peer Reviewed
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