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2012 Fiscal Year Final Research Report

Retinal Vascular Regeneration by Rectifying Angiogenic Directions

Research Project

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Project/Area Number 22689046
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKobe University

Principal Investigator

UEMURA Akiyoshi  神戸大学, 大学院・医学研究科, 特命助教 (30373278)

Co-Investigator(Renkei-kenkyūsha) FUKUSHIMA Yoko  神戸大学, 大学院・医学研究科, 研究員 (70647031)
Project Period (FY) 2010 – 2012
Keywords血管新生 / 内皮細胞 / 糸状仮足 / Sema3E / PlexinD1 / RhoJ / Arhgef15 / VEGF
Research Abstract

We attempted to develop a modality by which angiogenic directions are rectified in ischemic retinopathy. During development, binding of neuron-derived Sema3E to endothelial PlexinD1 activated RhoJ, thereby retracting disoriented angiogenesis. In a mouse model of ischemic retinopathy, intravitreal injections of Sema3E protein selectively prevented disoriented angiogenesis without affecting retinal vascular regeneration. Theses results present a new paradigm of vascular regeneration therapy that guides new blood vessels toward the ischemic retinas.

  • Research Products

    (25 results)

All 2013 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (11 results) Book (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells2012

    • Author(s)
      Kusuhara S, Fukushima Y, Fukuhara A, Jakt LM, Okada M, Shimizu Y, Hata M, Nishida K, Negi A, Hirashima M, Mochizuki N, Nishikawa S, Uemura A
    • Journal Title

      PLoS ONE

      Volume: 7 Pages: e45858

    • DOI

      DOI:10.1371/journal.pone.0045858

    • Peer Reviewed
  • [Journal Article] Angiopoietin-2 differentially regulates angiogenesis through Tie2 and integrin signaling2012

    • Author(s)
      Felcht M, Luck R, Schering A, Seidel P, Srivastava K, Hu J, Bartol A, Kienast Y, Vettel C, Loos EK, Kutschera S, Bartels S, Appak S, Besemfelder E, Terhardt D, Chavakis E, Wieland T, Klein C, Thomas M, Uemura A, Goerdt S, Augustin HG
    • Journal Title

      J Clin Invest

      Volume: 122 Pages: 1991-2005

    • Peer Reviewed
  • [Journal Article] Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival2012

    • Author(s)
      Toyofuku T, Nojima S, Ishikawa T, Takamatsu H, Tsujimura T, Uemura A, Matsuda J, Seki T, Kumanogoh A
    • Journal Title

      Genes Dev

      Volume: 26 Pages: 816-829

    • Peer Reviewed
  • [Journal Article] The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice2012

    • Author(s)
      Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M, Mochizuki N
    • Journal Title

      J Clin Invest

      Volume: 122 Pages: 1416-1426

    • Peer Reviewed
  • [Journal Article] FGD5 mediates pro-angiogenic action of vascular endothelial growth factor in human vascular endothelial cells2012

    • Author(s)
      Kurogane Y, Miyata M, Kubo Y, Nagamatsu Y, Kundu RK, Uemura A, Ishida T, Quertermous T, Hirata K, Rikitake Y
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Pages: 988-996

    • Peer Reviewed
  • [Journal Article] selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice2011

    • Author(s)
      Fukushima Y, Okada M, Kataoka H, Hirashima M, Yoshida Y, Mann F, Gomi F, Nishida K, Nishikawa S, Uemura A
    • Journal Title

      J Clin Invest

      Volume: 121 Pages: 1974-1985

    • Peer Reviewed
  • [Journal Article] Inhibition of semaphorin as a novel strategy for therapeutic angiogenesis2010

    • Author(s)
      Moriya J, Minamino T, Tateno K, Okada S, Uemura A, Shimizu I, Yokoyama M, Nojima A, Okada M, Koga H, Komuro I
    • Journal Title

      Circ Res

      Volume: 106 Pages: 391-398

    • Peer Reviewed
  • [Journal Article] 網膜血管新生におけるガイダンス分子の役割2010

    • Author(s)
      植村明嘉
    • Journal Title

      日本臨床

      Volume: 68 Pages: 349-353

  • [Journal Article] 網膜における生理的血管発生と病的血管新生2010

    • Author(s)
      植村明嘉
    • Journal Title

      実験医学

      Volume: 28 Pages: 2825-2830

  • [Journal Article] EphrinB2-EphB4 signals regulate formation and maintenance of funnel-shaped valves in corneal lymphatic capillaries

    • Author(s)
      Katsuta H, Fukushima Y, Maruyama K, Hirashima M, Nishida K, Nishikawa S, Uemura A
    • Journal Title

      nvest Ophthalmol Vis Sci

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] Mouse retinal angiogenesis as a model system of diabetic retinopathy2012

    • Author(s)
      Uemura A
    • Organizer
      2012 International Conference on Diabetes and Metabolism
    • Place of Presentation
      韓国
    • Year and Date
      2012-11-08
  • [Presentation] 網膜症における血管新生2012

    • Author(s)
      植村明嘉
    • Organizer
      第27回日本糖尿病合併症学会シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2012-11-02
  • [Presentation] The small GTPase RhoJ mediates Sema3E-induced contraction of 2nd endothelial cells2012

    • Author(s)
      Uemura A
    • Organizer
      Pacific Society of Vascular Biology
    • Place of Presentation
      韓国
    • Year and Date
      2012-10-31
  • [Presentation] Arhgef15 promotes angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells.2012

    • Author(s)
      Uemura A
    • Organizer
      17th International Vascular Biology Meeting
    • Place of Presentation
      ドイツ
    • Year and Date
      2012-09-17
  • [Presentation] RhoJ regulates endocytic trafficking of VEGFR2 and PlexinD1 in endothelial cells2012

    • Author(s)
      Uemura A
    • Organizer
      7th International Kloster Seeon Angiogenesis Meeting
    • Place of Presentation
      ドイツ
    • Year and Date
      2012-06-04
  • [Presentation] 眼内血管新生病の治療における新規創薬標的分子の同定2012

    • Author(s)
      植村明嘉
    • Organizer
      第89回日本生理学会大会シンポジウム
    • Place of Presentation
      松本
    • Year and Date
      2012-03-30
  • [Presentation] RhoJ mediates Sema3E-induced contraction of endothelial cells2012

    • Author(s)
      Uemura A
    • Organizer
      Keystone Symposia. Angiogenesis: Advances in Basic Science andTherapeutic Applications
    • Place of Presentation
      米国
    • Year and Date
      2012-01-17
  • [Presentation] Identification of G protein-related genes in angiogenic endothelial cells2011

    • Author(s)
      植村明嘉
    • Organizer
      第19回日本血管生物医学会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-12-09
  • [Presentation] 網膜血管の再生2011

    • Author(s)
      植村明嘉
    • Organizer
      第50回日本網膜硝子体学会総会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-12-04
  • [Presentation] Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy 9th in mice2011

    • Author(s)
      Uemura A
    • Organizer
      Korea-Japan Joint Symposium on Vascular Biology
    • Place of Presentation
      韓国
    • Year and Date
      2011-08-26
  • [Presentation] How to promote regeneration of functional capillaries in the ischemic retina2010

    • Author(s)
      Uemura A
    • Organizer
      World Ophthalmology Congress
    • Place of Presentation
      ドイツ
    • Year and Date
      2010-06-07
  • [Book] 血管新生研究の最先端2013

    • Author(s)
      植村明嘉
    • Total Pages
      112-118
    • Publisher
      医薬ジャーナル社
  • [Book] 血管生物医学事典2011

    • Author(s)
      植村明嘉
    • Total Pages
      183-184
    • Publisher
      朝倉書店
  • [Book] Encyclopedia of the Eye, Vol42010

    • Author(s)
      Uemura A
    • Total Pages
      204-211
    • Publisher
      Oxford: Academic Press
  • [Patent(Industrial Property Rights)] 新規な血管新生調節因子の利用2011

    • Inventor(s)
      植村明嘉、福嶋葉子、福原茂朋、望月直樹、西川伸一
    • Industrial Property Rights Holder
      植村明嘉、福嶋葉子、福原茂朋、望月直樹、西川伸一
    • Industrial Property Number
      特願 2011-238012
    • Filing Date
      2011-10-28

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Published: 2014-08-29  

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