2011 Fiscal Year Final Research Report
Analysis of information processing mechanisms of insulin temporal patterns
| Project/Area Number |
22700310
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KUBOTA Hiroyuki 東京大学, 大学院・理学系研究科, 助教 (40376603)
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| Project Period (FY) |
2010 – 2011
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| Keywords | システムズバイオロジー / インスリン / シグナル伝達 / 時間情報コーディング |
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| Research Abstract |
Blood insulin exhibits several temporal patterns. It is reported that the temporal patterns of insulin are important for regulation of metabolic functions. However, how insulin selectively regulates multiple metabolic functions remains unknown. We demonstrate that the AKT pathway can multiplex distinct patterns of insulin and the downstream molecules selectively decode the temporal patterns of insulin usingexperiments and simulation.
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