2011 Fiscal Year Final Research Report

Analysis of intrinsically disordered proteins based on molecular evolution

Research Project

Project/Area Number	22700318
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Bioinformatics/Life informatics
Research Institution	National Institute of Advanced Industrial Science and Technology
Principal Investigator	HIROSE Shuichi 独立行政法人産業技術総合研究所, 生命情報工学研究センター, 協力研究員 (60549898)
Project Period (FY)	2010 – 2011
Keywords	分子進化 / 遺伝子進化
Research Abstract	In order to find out distinctive features of intrinsically disordered proteins and means for classification of them, we conducted the bioinformatics analysis based on molecular evolution. As a result, two features, which are "ortholog distribution pattern in phylogenetic tree" and "change of disordered region proportion", were identified as features. Additionally, it was indicated that intrinsically disordered proteins can be classified based on the two features. Moreover, new knowledge concerning relationship between increase in disordered region and protein function acquisition was obtained.

(2 results)