2011 Fiscal Year Final Research Report
Molecular pathophysiology of autism-like behavior in glutamate transporter knockout mice.
| Project/Area Number |
22700328
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AIDA Tomomi 東京医科歯科大学, 難治疾患研究所, 助教 (50540481)
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| Project Period (FY) |
2010 – 2011
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| Keywords | グルタミン酸トランスポーター / 繰り返し行動 / 自閉症 / 強迫性障害 / トゥーレット症候群 |
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| Research Abstract |
Compulsive-repetitive behaviors are common core symptom that are shared between autism spectrum disorders and obsessive-compulsive spectrum disorders. The underlying pathogenic mechanisms of compulsive-repetitive behaviors are largely unknown. Here we show glutamate transporter conditional knockout mice exhibit compulsive-repetitive behaviors due to increased glutamate neural transmission. These findings demonstrate glutamatergic hyperactivity is important for pathogenesis of compulsive-repetitive behaviors.
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