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2011 Fiscal Year Final Research Report

The role of D-serine in epilepsy

Research Project

  • PDF
Project/Area Number 22700332
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionUniversity of Toyama

Principal Investigator

INOUE Ran  富山大学, 大学院・医学薬学研究部(医学), 助教 (70401817)

Project Period (FY) 2010 – 2011
Keywords分子 / 細胞神経科学
Research Abstract

In this study, we examined the effect of D-serine deficiency on the seizures induced by a single injection of pentylenetetrazole(PTZ) using SR knockout(KO) mice. We found that, compared with wild-type(WT) mice, SR-KO mice showed the attenuation of seizure expression in terms of a significantly shortened duration of generalized seizures and resistance to generalized clonic-tonic seizures. Consistently, immunohistochemical analysis of c-Fos demonstrated that the level of c-Fos labeling induced by high-dose PTZ in the cerebral cortex, hippocampal CA1, hippocampal CA3, and the basolateral nucleus of the amygdala in WT mice was significantly higher than that in SR-KO mice. Moreover, PTZ induced an increase in extracellular glutamate level in the dentate gyrus of WT mice at two different time phases. However, such a PTZ-induced increase in glutamate level was completely inhibited in SR-KO mice. The present findings suggest that SR may be a target for the development of new therapeutic strategies for epileptic seizures.

  • Research Products

    (9 results)

All 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Role of serine racemase in behavioral sensitization in mice after repeated administration of methamphetamine2012

    • Author(s)
      Horio M., Kohno M., Fujita Y., Ishima T., Inoue R., Mori H., Hashimoto K.
    • Journal Title

      PLoS One

      Volume: 7 Pages: e35494

    • Peer Reviewed
  • [Journal Article] Levels of D-serine in the brain and peripheral organs of serine racemase(Srr) knock-out mice2011

    • Author(s)
      Horio M., Kohno M., Fujita Y., Ishima T., Inoue R., Mori H., Hashimoto K.
    • Journal Title

      Neurochem. Int

      Volume: 59 Pages: 583-589

    • Peer Reviewed
  • [Journal Article] Serine racemase knockout mice2010

    • Author(s)
      Mori H., Inoue R.
    • Journal Title

      Chemistry & Biodiversity

      Volume: 7 Pages: 1573-1578

    • Peer Reviewed
  • [Presentation] ペンチレンテトラゾール誘発痙攣発作におけるD-セリンの機能解析2011

    • Author(s)
      井上蘭,原井朋美,藤田有子,田中亜由美,堀尾茉央,橋本謙二,森寿
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      20110914-17
  • [Presentation] セリンラセマーゼノックアウトマウスではペンチレンテトラゾール急性投与により誘発される痙攣発作に関連した変化が抑制される2011

    • Author(s)
      井上蘭,原井朋美,藤田有子,田中亜由美,堀尾茉央,橋本謙二,森寿
    • Organizer
      D-アミノ酸研究会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      20110909-10
  • [Presentation] Pentylenetetrazole-induced seizure is attenuated in serine racemase knockout mice2010

    • Author(s)
      Inoue R., Harai T., Hashimoto K., Tanaka A., Mori H.
    • Organizer
      Society For Neuroscience's 40th annual meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20101113-17
  • [Book] 「seriesモデル動物利用マニュアル」疾患モデルの作製と利用-脳・神経疾患,セリンラセマーゼ欠損マウス2011

    • Author(s)
      井上蘭,森寿
    • Total Pages
      189-194
    • Publisher
      株式会社エル・アイ・シー
  • [Book] Serine racemase knockout mice. D-Amino Acids in Chemistry, Lifesciences, and Biotechnology2010

    • Author(s)
      Mori H., Inoue R.
    • Total Pages
      257-262
    • Publisher
      Lifesciences, and Biotechnology
  • [Remarks]

    • URL

      http://bsd.neuroinf.jp/wiki/%E3%82%BB%E3%83%AA%E3%83%B3%E3%83%A9%E3%82%BB%E3%83%9F%E5%8C%96%E9%85%B5%E7%B4%A0

URL: 

Published: 2013-07-31  

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