Regulation of retinotopy by Wnt signaling in the higher order visual center

2011 Fiscal Year Final Research Report

• Project/Area Number: 22700333
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Kanazawa University
• Principal Investigator: SATO Makoto 金沢大学, フロンティアサイエンス機構, 特任准教授 (30345235)
• Project Period (FY): 2010 – 2011
• Keywords: 脳・神経 / 神経科学 / 神経回路 / 視覚系 / Wnt

Research Abstract

When visual information received in the retina is transmitted to the brain, the spatial order of retinal axons is preserved in the spatial order of their targets. Such retinotopic projections are observed throughout the visual system. However, molecular mechanisms that establish the retinotopy in the higher order visual center remain elusive. In this study, we focused on the roles of Wnt family proteins in the fly visual center and revealed key mechanisms that form the retinotopy in the higher order visual center.

Research Products

• [Journal Article] Concentric zones, cell migration and neuronal circuits in the Drosophila visual center (2011)
  • Author(s): Hasegawa, E., Kitada, Y., Kaido, M., Takayama, R., Awasaki, T., Tabata, T. and Sato, M.
  • Journal Title: Development Volume: 138 Pages: 983-993
  • DOI: doi:10.1242/dev.058370
  • Peer Reviewed
• [Journal Article] The Wnt5/Planar cell polarity pathway regulates axonal development of the Drosophila mushroom body neuron (2011)
  • Author(s): Shimizu, K., Sato, M. and Tabata, T.
  • Journal Title: Journal of Neuroscience Volume: 31 Pages: 4944-4954
  • DOI: DOI:10.1523/JNEUROSCI.0154-11.2011
  • Peer Reviewed
• [Journal Article] Fat/Hippo pathway regulates the progress of neural differentiation signaling in the Drosophila optic lob (2011)
  • Author(s): Kawamori, H., Tai, M. Sato, M., Yasugi, T. and Tabata, T.
  • Journal Title: Development Growth and Differentiation Volume: 53 Pages: 653-667
  • DOI: DOI:10.1111/j.1440-169X.2011.01279.x
  • Peer Reviewed
• [Journal Article] Robustness of the Dpp morphogen activity gradient depends on negative feedback regulation by the inhibitory Smad (2011)
  • Author(s): Ogiso, Y., Tsuneizumi, K., Masuda, N., Sato, M. and Tabata, T.
  • Journal Title: Development Growth and Differentiation Volume: 53 Pages: 668-678
  • DOI: DOI:10.1111/j.1440-169X.2011.01274.x
  • Peer Reviewed
• [Presentation] Molecular basis of the production of neuronal diversity in the Drosphipha visual center (2012)
  • Author(s): Suzuki, T., Kaido, M., Takayama, R. and Sato, M.
  • Organizer: Annual Drosophila Research Conference
  • Place of Presentation: Sheraton Chicago Hotel & Towers(USA)
  • Year and Date: 20120307-11
• [Presentation] Brain-specific-homeobox is required for the specification of neuronal types in the optic lobe (2011)
  • Author(s): Hasegawa, E., Kaido, M., Takayama, R., Tabata, T. and Sato, M
  • Organizer: Cold Spring Harbor Laboratory Meeting on Neurobiology of Drosophila
  • Place of Presentation: コールドスプリングハーバー研究所(USA)
  • Year and Date: 20111003-07
• [Presentation] ショウジョウバエ視覚中枢において神経細胞の多様性を産み出す分子機構の解析 (2011)
  • Author(s): 鈴木匠、海道雅子、高山理恵、佐藤純
  • Organizer: 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-12-13
• [Presentation] Concentric zones, cell migration and neuronal circuits in the Drosophila visual center (2010)
  • Author(s): Sato, M.
  • Organizer: Gordon Research Conference, Visual System Development
  • Place of Presentation: Il Ciocco Hotel and Resort(イタリア)
  • Year and Date: 2010-05-24
• [Book] ブレインサイエンス・レビュー2010 (2010)
  • Author(s): 佐藤純
  • Total Pages: 159-184
  • Publisher: クバプロ
• [Remarks]
  • URL: http://fsosato.w3.kanazawa-u.ac.jp/index.html