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2011 Fiscal Year Final Research Report

Molecular basis of CO_2 sensing in the mouse olfactory system

Research Project

  • PDF
Project/Area Number 22700341
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionNara Medical University

Principal Investigator

TAKAHASHI Hiroo  奈良県立医科大学, 医学部, 助教 (20390685)

Project Period (FY) 2010 – 2011
Keywords嗅細胞
Research Abstract

Mice can detect CO_2 at concentrations around the average atmospheric level by olfaction. Previous study reported that there is a unique subset of olfactory sensory neurons(OSNs), which act as a sensor for CO_2 in the mouse olfactory epithelium(OE). In this study, we found that at least two novel subsets of OSNs respond to CO_2.These results suggest that mice sense CO_2 with some subsets of OSNs in the OE.

  • Research Products

    (7 results)

All 2012 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] 5T4 Glycoprotein regulates the sensory input-dependent development of a specific subtype of newborn interneurons in the mouse olfactory bulb2012

    • Author(s)
      Yoshihara S, Takahashi H, Nishimura N, Naritsuka H, Shirao T, Hirai H, Yoshihara Y, Mori K, Stern P. L. and Tsuboi A
    • Journal Title

      The Journal of Neuroscience

      Volume: Vol.32 Pages: 2217-2226

    • DOI

      doi:10.1523/JNEUROSCI.5907-11.2012

    • Peer Reviewed
  • [Journal Article] 脳における匂い感覚地図の形成メカニズムFood and Food Ingredients Journal of Japan2011

    • Author(s)
      高橋弘雄、坪井昭夫
    • Journal Title

      和文総説

      Volume: Vol.216 Pages: 100-106

  • [Journal Article] Neuropilin-2 is required for the proper targeting of ventral glomeruli in the mouse olfactory bulb2010

    • Author(s)
      Takahashi H, Yoshihara S, Nishizumi H, and Tsuboi A
    • Journal Title

      Molecular and Cellular Neuroscience

      Volume: Vol.44 Pages: 233-245

    • DOI

      doi:10.1016/j.mcn.2010.03.010

    • Peer Reviewed
  • [Journal Article] 脳における匂い感覚地図の形成メカニズAroma Research2010

    • Author(s)
      高橋弘雄、吉原誠一、坪井昭夫
    • Journal Title

      和文総説

      Volume: Vol.11 Pages: 224-229

  • [Presentation] Molecular basis of CO_2 sensing in the mouse olfactory system2012

    • Author(s)
      高橋弘雄, 他
    • Organizer
      The International Symposium on Olfaction and Taste
    • Place of Presentation
      スウェーデンStockholm Waterfront
    • Year and Date
      2012-06-24
  • [Presentation] Molecular basis of CO_2 sensing in the mouse olfactory system2010

    • Author(s)
      高橋弘雄, 他
    • Organizer
      第33回日本神経科学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-09-03
  • [Remarks]

    • URL

      http://www.naramed-u.ac.jp/~amrc-lab1/

URL: 

Published: 2013-07-31  

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