2011 Fiscal Year Final Research Report
Regulation of neuronal function by intracellular protein trafficking
| Project/Area Number |
22700343
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | AMPA受容体 / stargazin / アダプタータンパク質 / 長期抑圧 / リン酸化 / PIP5K_Y661 / NMDA受容体 |
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| Research Abstract |
NMDA receptor activation leads to endocytosis of AMPA receptors. Although this process controls long-term depression(LTD) induction, how it is regulated by neuronal activities is not completely clear. We showed that the NMDA receptor activation controls AMPA receptor endocytosis and LTD induction by regulating PIP5K_Y661 activity and the interaction between stargazin and Adaptor Protein Complexes.
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[Journal Article] NMDA receptor-mediated PIP5K activation to produce PI(4, 5) P is essential for AMPA receptor endocytosis during LTD2011
Author(s)
Unoki T, Matsuda S, Kakegawa W, Van N. T, Kohda K, Suzuki A, Funakoshi Y, Hasegawa H, Yuzaki M, Kanaho Y
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Journal Title
These authors contributed equally Neuron
Volume: 73
Pages: 35-148
Peer Reviewed
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