2011 Fiscal Year Final Research Report
The functional analysis of a novel ubiquitin like posttranslational modifier UBL3
| Project/Area Number |
22700346
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Fujita Health University |
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Principal Investigator |
AGETA Hiroshi 藤田保健衛生大学, 総合医科学研究所, 助教 (40416649)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 分子・細胞神経科学 / 新規翻訳後修飾 |
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| Research Abstract |
By using a bioinformatical method, we identified UBL3 as a highly conserved posttranslational modifier. We found that UBL3 were localized at the plasma membrane and attached to other proteins like an ubiquitin protein. However, the functional role of UBL3 is still unknown. To elucidate roles of UBL3, we searched for interaction protein with UBL3.As a result, we identified several UBL3-binding proteins. One UBL3-binding protein enhanced UBL3ylation which is a posttranslational modification via UBL3.These findings suggest that UBL3 may play a pivotal role as an essential component of a novel membrane localization system.
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Research Products
(2 results)
