2011 Fiscal Year Final Research Report
Endocytic pathways controlling neuronal growth cone guidance
| Project/Area Number |
22700353
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TOJIMA Takuro 独立行政法人理化学研究所, 神経成長機構研究チーム, 研究員 (00373332)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 神経成長円錐 / 軸索ガイダンス / クラスリン依存性エンドサイトーシス / カルシニューリン / CaMキナーゼII / Cdk5 |
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| Research Abstract |
The neuronal growth cone navigates the axon along the correct path by sensing extracellular guidance cues. We previously demonstrated that, downstream of Ca2+signals, growth cone attraction and repulsion are driven by asymmetric exocytosis and endocytosis, respectively. In this project, we identified the signaling pathways that link Ca2+signals with endocytosis for bidirectional growth cone guidance.
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