2011 Fiscal Year Final Research Report
Cerebellar microstructures and their electrophysiological and functional properties
| Project/Area Number |
22700357
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
OZEKI Hirofumi 独立行政法人理化学研究所, 大脳皮質回路可塑性研究チーム, 研究員 (80553833)
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| Research Collaborator |
HASHIMOTO Mitsuhiro 独立行政法人理化学研究所, 旧橋本研究ユニット, ユニットリーダー (90311357)
HIRASE Hajime 独立行政法人理化学研究所, 神経グリア回路研究チーム, チームリーダー (90392084)
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| Project Period (FY) |
2010 – 2011
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| Keywords | チャンネルロドウプシン2 / マウス小脳皮質 / 縦縞構造 / マウス視覚野 / オプトジェネティクス / 2光子励起顕微鏡 |
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| Research Abstract |
Using adenoviral transfection, Channelrhodopsin-2 was expressed only onto specific Purkinje cells with the same birthday. Since the ChR2-positive Purkinje cells make remarkable microstructures within cerebellar cortex, I made a method to locally activate the Purkinje cells within the same structure and studied the effects on cerebellar network. I also applied the same method to mouse visual cortex.
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