2011 Fiscal Year Final Research Report

Molecular Mechanisms underlying acquisition of neuronal identity in olfactory sensory neurons

Research Project

Project/Area Number	22700364
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Nerve anatomy/Neuropathology
Research Institution	The University of Tokyo
Principal Investigator	TAKEUCHI Haruki 東京大学, 大学院・理学系研究科, 特任助教 (70548859)
Project Period (FY)	2010 – 2011
Keywords	神経回路網
Research Abstract	The assembly of the functional neural circuit is one of the most complex developmental processes. Unraveling the mechanisms involved is vital for advancing basic scientific understanding. In the mouse olfactory system, expressed olfactory receptor(OR) plays a pivotal role in the axonal projection of olfactory sensory neurons(OSNs). However, it remains unknown about the nature of the signals for activating OR proteins. In this study, we focused on ligand-independent basal activity and found that each OR has a unique level of basal activity and signaling levels of the OR-derived basal activity regulate the projection site of OSN axons.

(4 results)