2012 Fiscal Year Final Research Report
Visualization of pathogenic mechanism of parkinson's disease with Keima, the novel autophagy probe.
| Project/Area Number |
22700381
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KATAYAMA Hiroyuki 独立行政法人理化学研究所, 細胞機能探索技術開発チーム, 研究員 (00415126)
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| Project Period (FY) |
2010 – 2012
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| Keywords | オートファジー / パーキンソン病 / ミトコンドリア / マイトファジー / イメージング / 蛍光タンパク質 / Keima、Parkin |
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| Research Abstract |
We produced Keima, a novel autophagy probe. Because the signal of Keima remains and accumulates after termination of autophagy, this probe has high sensitivity and can determines total amount of autophagy. While this probe can detect not only macroautophagy, but also other autophagy. mt-mKeima, a mitochondria targeting construct, can detect mitophagy. This probe has been distributed and used in some dozen laboratory.
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