2011 Fiscal Year Final Research Report
Functional analysis of novel NYAP family proteins
| Project/Area Number |
22700391
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 神経細胞 / チロシンキナーゼ / PI3K / WAVE |
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| Research Abstract |
The phosphoinositide 3-kinase(PI3K) pathway has been extensively studied in neuronal function and morphogenesis. However, the precise molecular mechanisms of PI3K activation and its downstream signalling in neurons remain elusive. In this study, we demonstrated that the NYAPs bridge a PI3K-WAVE1 association by simultaneously interacting with PI3K and the WAVE1 complex. Disruption of the NYAP genes in mice affects brain size and neurite elongation.
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Research Products
(10 results)
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[Journal Article] NYAP : a phosphoprotein family that links PI3K to WAVE1 signaling in neurons2011
Author(s)
Yokoyama K, Tezuka T, Kotani M, Nakazawa T, Hoshina N, Shimoda Y, Kakuta S, Sudo K, Watanabe K, Iwakura Y, and Yamamoto T.
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Journal Title
EMBO J
Volume: 30
Pages: 4739-4754
DOI
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[Journal Article] NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala2010
Author(s)
Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattori S, Hashimoto R, Umemori H, Manabe T, Yamamoto T, and Nakazawa T.
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Journal Title
Mol. Brain
Volume: 3
Pages: 37
DOI
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