2011 Fiscal Year Final Research Report
Molecular mechanisms of synapse formation by mental disorder-related gene products
| Project/Area Number |
22700392
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Keywords | 発生 / 分化 / 老化 |
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| Research Abstract |
IL-1 receptor accessory protein-like 1(IL1RAPL1) is responsible for X-linked mental retardation and autism. Expression of IL1RAPL1 in cultured cortical neurons enhanced synapse formation while knockdown of IL1RAPL1 suppressed synaptogenesis. Postsynaptic IL1RAPL1 mediated excitatory synapse formation through trans-synaptic interaction with presynaptic protein tyrosine phosphatase(PTP)δ.
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Research Products
(34 results)
