2011 Fiscal Year Final Research Report
Cholesterol metabolite-dependent regulation of synaptic development
| Project/Area Number |
22700393
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kagawa University (2011)
Tokyo Medical and Dental University (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | BDNF / コレステロール / ヒドロキシコレステロール / 神経細胞 / シナプス |
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| Research Abstract |
Our previous study found that BDNF induced the synthesis of 24-hydroxycholesterol(24HC). However the roles of 24HC on CNS are not known. To better understand, we here investigate the effect of 24HC on primary neurons or astrocytes. The results indicated a possibility that, while 24HC was not involved in the BDNF-dependent effect on synapse development and dendritic morphology, 24HC did transduce the feedback signal to suppress the effect of BDNF.
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[Journal Article] A high cholesterol diet given to apolipoprotein E-knockout mice has a differential effect on the various neurotrophin systems in the hippocampus2011
Author(s)
Wang ZY, Miki T, Ding Y, Wang SJ, Gao YH, Wang XL, Wang YH, Yokoyama T, Warita K, Ohta K, Suzuki S, Ohnishi T, Obama T, Bedi KS, Takeuchi Y, Shan BE.
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Journal Title
Metab Brain Dis
Volume: 26(3)
Pages: 185-94
Peer Reviewed
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