2011 Fiscal Year Final Research Report
Psychiatric dysfunction regulated by NADPH oxidase
| Project/Area Number |
22700397
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
IBI Masakazu 京都府立医科大学, 医学研究科, 助教 (10336539)
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| Project Period (FY) |
2010 – 2011
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| Keywords | NADPHオキシダーゼ / 活性酸素種 / 精神障害 |
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| Research Abstract |
The involvement of reactive oxygen species(ROS) in anxiety and mood disorders has been reported ; however, the source of ROS in the nervous system has not been identified. NADPH oxidase is a superoxide-generating enzyme composed of multiple subunits including a membrane-spanning catalytic subunit, NOX. ROS derived from NOX1/NADPH oxidase, which possess a newly identified catalytic subunit, appear to play a key role in stress-induced anxiety and depressive-like behaviors, possibly by regulating activation of the hypothalamic-pituitary-adrenal axis and decrease in BDNF level.
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[Journal Article] A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditis elegans2011
Author(s)
Aoki R, Yagami T, Sasakura H, Ogura K, Kajihara Y, Ibi M, Miyamae T, Nakamura F, Asakura T, Kanai Y, Misu Y, Iino Y, Ezcurra M, Schafer WR, Mori I, Goshima Y
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Journal Title
J. Neurosci
Volume: 31
Pages: 16603-16610
DOI
Peer Reviewed
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