2011 Fiscal Year Final Research Report
Sulfation patterns and molecular mechanisms of Chondroitin sulfate polysaccharide in regulating the neuronal regeneration
| Project/Area Number |
22700401
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 幹細胞生物学 / 再生 / 修復 |
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| Research Abstract |
Chondroitin sulfate(CS) is an important component of the cell surface and extracellular matrix in the central nervous system. CS is divided into at least four subclasses, known as CS-A, CS-C, CS-D and CS-E, on the basis of the sulfation patterns of their major disaccharide units. The CS-E polysaccharide, but not CS-A, CS-C or CS-D polysaccharide, was changed cell adhesion and mourphology of cultured neuronal cells. The action of CS-E polysaccharide is mediated through VEGF receptor/eNOS and VEGF receptor/Raf-1/Rb signalings.
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