2011 Fiscal Year Final Research Report
Analysis of HDAC6-deficient mice that showing behavioral abnormalities related to psychiatric disorders
| Project/Area Number |
22700408
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
FUKADA Masahide 愛知県心身障害者コロニー発達障害研究所, 発生障害学部, 研究員 (80414019)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 精神・神経疾患の病態と治療 / アセチル化 |
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| Research Abstract |
Here we demonstrate the crucial roles of Hdac6(histone deacetylase 6) deacetylase activity in the expression of emotional behavior in mice. Moreover, administration of Hdac6-specific inhibitor replicated antidepressant-like effect in mice. In good agreement with behavioral phenotypes of Hdac6-deficient mice, Hdac6 dominantly localizes to the dorsal and median raphe nuclei, which are involved in emotional behaviors. These findings will help understand the etiology of depression, and provide a new therapeutic target for depression.
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