2011 Fiscal Year Final Research Report
Analysis of inhibitory interneuron subtypes with distinct subcellular domain innervation to projection neurons in the mouse olfactory bulb
| Project/Area Number |
22700409
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NARITSUKA Hiromi 東京大学, 大学院・医学系研究科, 特任研究員 (00511388)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 嗅球 / 抑制性介在ニューロン / 成体神経新生 |
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| Research Abstract |
Previous studies of neuronal circuits in the rodent olfactory bulb focused mainly on the interplay between projection neurons and dendritic-targeting inhibitory interneurons. In this study, in addition to the dendritic-targeting subtype, we studied the perisomatic-targeting subtype of inhibitory interneurons to identify the functional differentiation of these subtypes to elucidate the information processing in the olfactory bulb. We found that granule cells show subtype specific electrophysiological properties, timing of cell generation and sensory input-dependent morphological changes.
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