2011 Fiscal Year Final Research Report
Control of neural circuit formation using light-regulated adenylyl cyclase in vivo.
| Project/Area Number |
22700410
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ISHII Tomohiro 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (60549947)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 神経科学 / 脳・神経 / 発生・分化 / シグナル伝達 / 遺伝学 |
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| Research Abstract |
To understand how cAMP is used to exert various functions in mouse olfactory sensory neurons(OSNs), we generated transgenic mice in which PAC, photo-activated adenylate cyclase, is expressed under the control of the mouse olfactory receptor promoter. PAC was detected throughout OSN including dendrites and axons, allowing local activation of PAC. We are currently analyzing the function of cAMP in neural circuit formation by regulating PAC activity using light.
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