The role of neuronal nitric oxide synthase-expressing neurons in the regulation of synaptic plasticity in the visual cortex

2011 Fiscal Year Final Research Report

• Project/Area Number: 22700412
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Nagoya University
• Principal Investigator: ENDO Toshiaki 名古屋大学, 環境医学研究所, 准教授 (30353436)
• Project Period (FY): 2010 – 2011
• Keywords: 視覚野 / 一酸化窒素合成酵素 / 大脳皮質

Research Abstract

The properties of neuronal nitric oxide synthase(nNOS)-positive neurons in the mouse visual cortex were examined. In vitro electrophysiological experiments revealed that substance P activate nNOS neurons and induce a rise in intracellular Ca^<2+>. This study provide important fundamental basis to understand the regulation of the synaptic plasticity in the visual cortex.