2011 Fiscal Year Final Research Report
Analysis of IL-1/IL-17 system-dependent promoting mechanisms for development of colon cancer using model mice
| Project/Area Number |
22700448
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Shinshu University |
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Principal Investigator |
KAKUTA Shigeru 信州大学, ヒト環境科学研究支援センター, 助教 (80345032)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 疾患モデル / 大腸がん / サイトカイン / IL-17 / IL-1 |
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| Research Abstract |
To elucidate the role of pro-inflammatory cytokines, IL-1/IL-17 family members, in development of intestinal polyps, the molecular mechanisms were analyzed using ApcMin mice, as a model of colon cancer. We found that deficiency of IL-17A and/or IL-17F in ApcMin mice caused suppression of intestinal polyp formation, and administration of neutralizing antibodies against IL-17A and/or IL-17F reduced development of polyps. These results suggest that endogenous IL-17A/F promote polyp formation and neutralizing antibodies are applied to therapeutic agent for colon cancer.
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[Journal Article] a phosphoprotein family that links PI3K to WAVE1 signalling in neurons2011
Author(s)
Yokoyama K, Tezuka T, Kotani M, Nakazawa T, Hoshina N, Shimoda Y, Kakuta S, Sudo K, Watanabe K, Iwakura Y, Yamamoto T
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Journal Title
EMBO J
Volume: 30
Pages: 4739-4754
DOI
Peer Reviewed
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[Journal Article] TNF, but Not IL-6 and IL-17, Is Crucial for the Development of T Cell-Independent Psoriasis-Like Dermatitis in Il1rn-/-Mice2010
Author(s)
Nakajima A, Matsuki T, Komine M, Asahina A, Horai R, Nakae S, Ishigame H, Kakuta S, Saijo S, and Iwakura Y
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Journal Title
J Immunol
Volume: 185
Pages: 1887-1893
DOI
Peer Reviewed
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