2011 Fiscal Year Final Research Report
Development of infertility treatment model using infertile mice and iPS cells
| Project/Area Number |
22700454
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Laboratory animal science
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
ISOTANI Ayako 大阪大学, 微生物病研究所, 助教 (20444523)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 生殖細胞 / 不妊 / 疾患モデル / iPS細胞 |
|---|
| Research Abstract |
Infertility treatment for patients with germ cell loss does not exist at all. In this study, we attempt to develop a germ cell loss treatment model using a XXY type mouse which has the sex chromosome abnormality as Klinefelter' s syndrome model. First, in order to regenerate the germ cells, we attempted the establishment of induced pluripotent stem cell(iPS). Some iPS cell-like lines were able to establish. However, the foreign gene could not be removed from iPS cell-like lines. As a result, the regeneration of germ cells did not reach.
|
-
-
[Journal Article] A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening2011
Author(s)
Horie, K., Kokubu, C., Yoshida, J., Akagi, K., Isotani, A., Oshitani, A., Yusa, K., Ikeda, R., Huang, Y., Bradley, A., and Takeda, J.
-
Journal Title
Nat Methods
Volume: 8
Pages: 1071-1077
DOI
Peer Reviewed
-
-
-
