2013 Fiscal Year Final Research Report
Immunotherapy with photodynamic vaccination for infection disease.
| Project/Area Number |
22700463
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MIYAZAKI Kozo 東京大学, 医学(系)研究科(研究院), 特任研究員 (40372164)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 光線力学的免疫治療 / 生体防御 / 生体制御 |
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| Research Abstract |
In this study, we carried out immunotherapy with photodynamic vaccination for infection disease in vitro and in vivo. The polyion complex micelle which made with PEG-pLLys(12-46) and DPc was incorporated to lysosome within four hours. Additionally, this micelle induced CD8 positive and IFNg secreted T cells after photo irradiation with laser. However, this reaction cannot detect the memory T cells. In future, we need to verification of immunological memory reaction in this immunotherapy.
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[Journal Article] Multicompartment micelles with adjustable poly(ethylene glycol) shell for efficientin vivo photodynamic therapy2014
Author(s)
Synatschke CV, Nomoto T, Cabral H, Fortsch M, Toh K, Matsumoto Y, Miyazaki K, Hanisch A, Schacher FH, Kishimura A, Nishiyama N, Muller AH, Kataoka K
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Journal Title
ACS Nano
Volume: 8(2)
Pages: 1161-1172
Peer Reviewed
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[Journal Article] 新規開発した膀胱がん対応型均質照射型光ファイバーによるPDT 効果増強2010
Author(s)
宮崎幸造, 守本祐司, 熊谷康顕, 福島重人, 堀江壮太, 村岡未帆, 胡尉之, 中楯健一, 金田恵司, 前川康弘, 四ノ宮成祥, 西山伸宏, 片岡一則
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Journal Title
日本レーザー医学会誌
Volume: 31(2)
Pages: 122-130
Peer Reviewed
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[Presentation] 新規開発した均質光照射ファイバープローブを用いたPDT システム : 大型動物を用いた前臨床試験による安全性と操作性の検証2010
Author(s)
宮崎幸造, 守本祐司, 村岡未帆, 伊藤敬一, 藤田真敬, 熊谷康顕, 福島重人, 堀江壮太, 四ノ宮成祥, 西山伸宏, 片岡一則
Organizer
第31回日本レーザー医学会総会
Place of Presentation
愛知、ウィンクあいち
Year and Date
20101100
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