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2012 Fiscal Year Final Research Report

Application of Fluorescent Metallo-Glycolipid for Targeting CancerCells

Research Project

  • PDF
Project/Area Number 22700483
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo University of Technology

Principal Investigator

OKADA Tomoko  東京工科大学, 片柳研究所, 研究員 (60409795)

Project Period (FY) 2010 – 2012
Keywords糖脂質 / 蛍光金属錯体 / 膜融合 / 癌細胞
Research Abstract

A novel metallo-glycolipid was designed and synthesized for giving a fluorescent carbohydrate probe that was potentially incorporated into a biological membrane. The metallo-glycolipid was succeeded in giving a fluorescent liposome with carbohydrates placed on a biomimetic liposomal membrane. The liposome was used for evaluateing recognition ability of carbohydrate to lectin. Specific binding events between lectin and carbohydrates on the liposomal surface was proved by the affinity evaluation with a fluorescent polarization analysis. Moreover, uptake of the metallo-glycocluster by HeLa cell was observed by fluorescent microscopy. These results suggest application of the metallo-glycolipid to a targeting agent for a cancer cell.

  • Research Products

    (6 results)

All 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results)

  • [Journal Article] Intricate Recognition of Glycolipid-like Compounds by HIV-1 Envelope Proteins Evaluated with Surface Plasmon Resonance Imaging2012

    • Author(s)
      T. Okada, A. Kimura, H. Miura, T.Nishiyama, M. Mori, J. Suzuki, M. Ogiso, K. Matsuoka, T. Sato, K. Hatanaka, N. Minoura.
    • Journal Title

      J. Carbohydr. Chem.

      Volume: 31(7) Pages: 584 - 597

    • DOI

      DOI:10.1080/07328303.2012.682190

    • Peer Reviewed
  • [Journal Article] Application of Functionalized Metallo-glycoclus- ters2011

    • Author(s)
      T. Okada.
    • Journal Title

      Trends in Glycosci. and Glycotechnol

      Volume: 23 (134) Pages: 284-291

    • DOI

      DOI:10.4052/tigg.23.284

    • Peer Reviewed
  • [Journal Article] Fluorescence Emission and Polarization Analyses for Evaluating Binding of Ruthenium Metalloglycoclusters to Lectins and Tetanus Toxin C-Fragment2011

    • Author(s)
      T. Okada, N. Minoura
    • Journal Title

      J. Biomed. Opt

      Volume: 16 (3) Pages: 037001

    • DOI

      DOI:10.1117/1.3558727

    • Peer Reviewed
  • [Presentation] 脂質を持つ新規なルテニウム錯体型糖鎖プローブ分子を利用した分子認識能評価2012

    • Author(s)
      田野倉大智、今泉竜一、岡田朋子、箕浦憲彦
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶応大学(神奈川県)
    • Year and Date
      2012-03-25
  • [Presentation] 糖鎖とレクチン間の相互作用を評価するためのルテニウム錯体型糖脂質の創製2011

    • Author(s)
      田野倉大智、今泉竜一、岡田朋子、箕浦憲彦
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2011-09-12
  • [Presentation] Application of ruthenium metalloglycocluster for affinity evaluation between carbohydrates and lectins by fluorescence emission and polarization2010

    • Author(s)
      T. Okada, T. Makino, N. Minoura
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Kamehameha Halls (Honolulu, USA)
    • Year and Date
      2010-12-19

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Published: 2014-08-29  

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