2012 Fiscal Year Final Research Report
Development of functional polymer-siRNA conjugates for siRNA delivery
| Project/Area Number |
22700489
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MIYATA Kanjiro 東京大学, 大学院・医学系研究科, 助教 (50436523)
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| Project Period (FY) |
2010 – 2012
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| Keywords | siRNA デリバリー / バイオコンジュゲート材料 |
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| Research Abstract |
In this study, a smart siRNA-polymer conjugate was developed withan endosome-disrupting polymer via an acidic pH-responsive linkage. Ultimately, theconjugate provided siRNA with enhanced blood circulation property, and further achievedefficient gene silencing in cultured cells, probably due to facilitated endosomal escape ofsiRNA.
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