2011 Fiscal Year Final Research Report
Visualization of nanomaterials and immune responses to them in infection barrier-tissue
| Project/Area Number |
22700491
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka University |
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Principal Investigator |
FUJII Fumihiko 大阪大学, 免疫学フロンティア研究センター, 特任助教 (40374657)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ナノマテリアル / 免疫応答 / バイオイメージング |
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| Research Abstract |
To visualize the dynamics of nanomaterials and immune responses in tissue, we have developed two techniques described below. 1. In addition to three dimensional motion of nanomaterials, their rotational motion is also crucial to reveal their dynamics in tissue. Thus, we synthesized polarized-semiconductor nanocrystals and demonstrated rotational single particle tracking of the nanomaterial. 2. Semiconductor nanocristals induced apoptosis in a specific condition. Furthermore, we confirmed that macrophages phagocyte the apoptotic cells.
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