2011 Fiscal Year Final Research Report
Development of highly-selective antimicrobial agents based on the concept of polymer architecture
| Project/Area Number |
22700494
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
YASUHARA Kazuma 奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (90545716)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 抗菌ポリマー / ポリマー・アーキテクチャ / 脂質二分子膜 / 両親媒性ポリマー / 抗抗生物質 |
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| Research Abstract |
In this study, we developed novel antimicrobial polymers inspired by the features of natural host-defense peptides. Membrane perturbation, which is utilized in this study, is promising approach to achieve antimicrobial activity with minimized production of drug-resistant bacteria. It was clarified that we can control interaction of the polymers with cell membranes by proper tuning of polymer structure. As a result, antimicrobial activity and toxicity to mammalian cells can be tuned by changing polymer structure.
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