2011 Fiscal Year Final Research Report
Development of new type of temperature-responsive cell culture surfaces with stretchable properties
| Project/Area Number |
22700496
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | PDMS / poly(N-isopropylacrylamide) / 電子線照射 / 超薄膜 / 細胞シート工学 |
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| Research Abstract |
A method of mechanical-assisted control of the polymer thickness and density of temperature-responsive cell culture surfaces was developed by grafting PIPAAm onto PDMS surfaces. Hydrophobicity of the PIPAAm-PDMS surfaces was readily controlled by stretching the surfaces. Further investigation of PIPAAm-PDMS surfaces demonstrated that this hydrophobicity control is because the polymer thickness and density is altered by the stretching. This result suggests that such control may attain producing cell adhesive surfaces appropriate for variety of target cells by stretching one PIPAAm-PDMS surfaces.
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