2011 Fiscal Year Final Research Report
Basic research on high-frequency pulsed electric field cancer treatment
| Project/Area Number |
22700511
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical systems
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| Research Institution | Kumamoto University |
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Principal Investigator |
ABE Keisuke 熊本大学, 大学院・自然科学研究科, COEリサーチ・アソシエイト (10535652)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 臓器保存 / 治療システム / 高周波高電界パルスがん治療 |
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| Research Abstract |
In this study, we found that nanosecond pulsed electric field(nsPEF) caused apoptosis like death to cancer cells. nsPEF(120ns width) promoted Ca^<2+> influx to cytoplasm, and Ceramide was expressed on cell membrane. These factors activated endoplasmic reticulum stress signal and caused apoptosis. Moreover, Intense Burst Sinusoidal Electric Field(3-10MHz) cannot damaged cell membrane. In case of a certain low energy, it activated cell proliferation.
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