2011 Fiscal Year Final Research Report

Study of activation mechanism of satellite cell : Basis for elucidate an efficient training method

Research Project

Project/Area Number	22700530
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Rehabilitation science/Welfare engineering
Research Institution	Kanazawa University
Principal Investigator	TANAKA Shoji 金沢大学, 保健学系, 助教 (70422657)
Project Period (FY)	2010 – 2011
Keywords	リハビリテーション / 骨格筋 / 肥大
Research Abstract	We investigated the role of hepatocyte growth factor in the satellite cell mechanism of activation related to the skeletal muscle hypertrophy in vivo in rat. The results show that whereas the levels of the hepatocyte growth factor receptor and that of the muscle differentiation factor increased in response to muscle load, the levels of hepatocyte growth factor remained unchanged. These results suggest that the qualitative changes rather than quantitative changes of hepatocyte growth factor may be more important for the satellite cell activation.