2011 Fiscal Year Final Research Report

Effects of voluntary exercise during early postnatal periods on the development of emotion regulation

Research Project

Project/Area Number	22700591
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Physical education
Research Institution	Yamaguchi University
Principal Investigator	ISHIKAWA Junko 山口大学, 大学院・医学系研究科, 助教 (30570808)
Project Period (FY)	2010 – 2011
Keywords	幼少期運動 / 前頭前野 / 発達
Research Abstract	The present study investigated the effect of voluntary exercise during early postnatal period on the abnormal behaviors and developmental disruption of prefrontal cortex induced by early weaning(EW), which is widely used as early life stress. EW caused hyper locomotor activity in the novelty in juvenile and adult animals, whereas this adverse effect of EW was not observed in adult animals which have been exercised voluntary began simultaneously with EW until normal weaning period. In addition, voluntary exercise after EW until normal weaning period prevented disruption of monoaminergic axon development and morphological changes of the pyramidal cell in the prefrontal cortex induced by EW. The present study clearly demonstrated the beneficial effects of voluntary exercise during early postnatal period.