2012 Fiscal Year Final Research Report
The effects of exercise-inducible factors on lipid metabolism in adipocytes
| Project/Area Number |
22700652
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脂質代謝 / 脂肪分解 / 脂肪滴 / メタボリックシンドローム / 肥満 / 運動 / ミトコ ンドリア |
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| Research Abstract |
The study investigated the cellular origin and physiological significance of micro lipid droplets (mLDs) that emerge in the cytoplasm during active lipolysis, as well as the roles of key liplolytic proteins on mLDs in differentiated 3T3-L1 adipocytes. The results suggest that, besides the surface of pre-existing central LDs, LD-associated proteins are actively involved in lipolysis on mLDs that are formed by fatty acids re-esterification. Furthermore, the lipolytic activity was increased by exercise-inducible factors such as H2O2, lactate-inducible signals, increased cellular calcium levels, AMP kinase, and nitric oxide inaccordance with elevated levels of LD-associated proteins and mitochondrial biogenic signaling.
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[Journal Article] Active involvement of micro-lipid droplets and lipiddroplet-associated proteins in hormone-stimulated lipolysis in adipocytes2012
Author(s)
Hashimoto T, Segawa H, Okuno M, Kano H, Hamaguchi HO, Haraguchi T, Hiraoka Y, Hasui S, Yamaguchi T, Hirose F, Osumi T
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Journal Title
Journal of Cell Science
Volume: 125(24)
Pages: 6127-6136
DOI
Peer Reviewed
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[Journal Article] Perilipin 5,a lipid droplet-binding protein, protects the heart from oxidative burden by sequestering fatty acid from excessiveoxidation2012
Author(s)
Kuramoto K, Okamura T, Yamaguchi T, Nakamura TY, Wakabayashi S, Morinaga H, Nomura M, Yanase T, Otsu K, Usuda N, Matsumura S, Inoue K, Fushiki T, Kojima Y, Hashimoto T,Sakai F, Hirose F, Osumi T
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Journal Title
Journal of BiologicalChemistry
Volume: 287(28)
Pages: 23852-23863
DOI
Peer Reviewed
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