2011 Fiscal Year Final Research Report

Metabolism of dietary Mg during exercise and preventive effect of Mg on chronic disease

Research Project

Project/Area Number	22700654
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Sports science
Research Institution	Josai International University
Principal Investigator	SAKAI Kensuke 城西国際大学, 薬学部, 准教授 (70406784)
Project Period (FY)	2010 – 2011
Keywords	スポーツ栄養学
Research Abstract	Apparent Mg absorption in exercised rats was higher than that in sedentary rats. In addition, decrease in serum Mg level and increase in amount of Mg and expression of TRPM7 protein in skeletal muscle were observed in exercised rats. Moreover, there are positive relationship between amount of skeletal Mg level and gluco-regulatory enzymes(PFK and PK). These results suggested exercise might induce Mg influx into skeletal muscle. On the other hand, increase in amount of dietary Mg improved the expression of TRPM7 levels, but did not affect the amount of skeletal Mg levels. This result confused our hypothesis, and the mechanism of Mg metabolism during exercise was still unclear. Now, we examine whether metabolic acidosis induced by exercise affect Mg influx and distribution.